{"id":"W2951131565","doi":"10.1038/s41418-019-0362-1","title":"ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells","year":2019,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Canadian Imperial Bank of Commerce; Government of Canada; Dalhousie Medical Research Foundation","keywords":"Biology; Cancer stem cell; Triple-negative breast cancer; Cancer research; Gene expression; Stem cell; Aldehyde dehydrogenase; Transcriptome; Gene; Molecular biology; Cancer; Cell biology; Breast cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009329108,0.0002168437,0.0002108232,0.00008605733,0.0001220967,0.00008259548,0.00009321918,0.0002043456,0.00005731166],"category_scores_gemma":[0.000004699246,0.0002100933,0.00008814316,0.00007920987,0.00003471103,0.00001352431,0.00009813224,0.0001079941,0.00000322545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003799395,"about_ca_system_score_gemma":0.00008109524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009327265,"about_ca_topic_score_gemma":0.00001280162,"domain_scores_codex":[0.9987282,0.00002906325,0.000204655,0.0005266105,0.0001752381,0.000336223],"domain_scores_gemma":[0.9993896,0.00001143948,0.0001228785,0.0001920132,0.0001410658,0.0001430393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003060414,0.00005426895,0.0002904465,0.0001403495,0.00007755686,0.000001032166,0.00009476411,0.000130565,0.9960254,0.00002343519,0.0001428551,0.002713274],"study_design_scores_gemma":[0.003282692,0.00024222,0.004814792,0.00005051731,0.00006305909,0.000009511386,0.00005785059,0.02714608,0.963899,0.00006096933,0.0001159034,0.00025745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8314879,0.0005285458,0.1665204,0.00006172634,0.0002420061,0.0008518778,0.0002224929,0.00001047372,0.00007460175],"genre_scores_gemma":[0.9967653,0.0003373965,0.0003762411,0.00007606023,0.0001167266,0.00006725846,0.0002094155,0.00003843257,0.00201323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1661441,"threshold_uncertainty_score":0.8567355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008033570561814784,"score_gpt":0.2337733955866557,"score_spread":0.2257398250248409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}