{"id":"W2951131794","doi":"10.1371/journal.pntd.0005816","title":"Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity","year":2017,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Agence Nationale de la Recherche; La Trobe University; UNICEF; Wellcome Trust; Wellcome; World Health Organization","keywords":"Ivermectin; Biology; Onchocerca volvulus; Genetics; Quantitative trait locus; Onchocerciasis; Genetic diversity; Genotyping; Genetic variation; Population; Candidate gene; Evolutionary biology; Gene; Genotype; Zoology; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002181341,0.000190178,0.0001959471,0.0005075913,0.0002111418,0.0003203398,0.0001346536,0.0001914999,0.00114151],"category_scores_gemma":[0.0004861029,0.00008214766,0.0002240286,0.0004778306,0.0002342845,0.0001192611,0.0002521302,0.0002628037,0.0001198655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390873,"about_ca_system_score_gemma":0.0001379085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001870443,"about_ca_topic_score_gemma":0.004002296,"domain_scores_codex":[0.9998317,0.0000185746,0.000007779179,0.00008578985,0.00002903663,0.00002704264],"domain_scores_gemma":[0.9997359,0.00008019576,0.0001110512,0.00001837487,0.00002516975,0.00002933608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004938355,0.0000614708,0.3121943,0.0002972357,0.000433848,0.0002061465,0.000268256,0.001234642,0.6590894,0.0002694608,0.0006259981,0.02482536],"study_design_scores_gemma":[0.00000712578,0.00007318536,0.99275,0.00001381419,0.00007137088,0.0001292135,0.0001039933,0.001077277,0.004903939,0.0001017666,0.0007605216,0.000007718942],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974286,0.0003914621,0.0005678035,0.00003363486,0.000005470893,0.00000602118,0.001235994,0.00003277728,0.0002982722],"genre_scores_gemma":[0.9978793,0.0001527848,0.0004021135,0.00006307779,0.000003837212,0.00001013376,0.001217199,0.00001254337,0.0002590529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001870443,"threshold_uncertainty_score":0.00381875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295344755802724,"score_gpt":0.289100606666218,"score_spread":0.2761471591081907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}