{"id":"W2951131794","doi":"10.1371/journal.pntd.0005816","title":"Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity","year":2017,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Agence Nationale de la Recherche; La Trobe University; UNICEF; Wellcome Trust; Wellcome; World Health Organization","keywords":"Ivermectin; Biology; Onchocerca volvulus; Genetics; Quantitative trait locus; Onchocerciasis; Genetic diversity; Genotyping; Genetic variation; Population; Candidate gene; Evolutionary biology; Gene; Genotype; Zoology; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00002522005,0.0002956591,0.001122293,0.0003656154,0.0002396956,0.00005377694,0.0001664568,0.00008113897,0.00009243193],"category_scores_gemma":[0.006314647,0.0002528326,0.0003402822,0.0004944105,0.000443407,0.00009653562,0.00015099,0.0001568776,0.000009706585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001893314,"about_ca_system_score_gemma":0.0003109349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002934105,"about_ca_topic_score_gemma":0.0001101466,"domain_scores_codex":[0.9971607,0.0005768132,0.0003868616,0.0005960299,0.0007252906,0.000554323],"domain_scores_gemma":[0.9958232,0.001446261,0.0002468923,0.0007787746,0.0005449241,0.001159935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01307405,0.00188541,0.879711,0.0001249356,0.005406297,0.0004805128,0.0001363512,0.00001948502,0.09825828,0.000005532388,0.0004241389,0.0004740163],"study_design_scores_gemma":[0.002718735,0.0009544038,0.9780462,0.0001317003,0.006229155,0.000004880328,0.00003472295,0.0004623886,0.01112239,0.00006871585,0.00003058242,0.0001960728],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937711,0.00114944,0.0003513003,0.0008914637,0.00001456668,0.0009272433,0.002796803,0.00004538588,0.00005265896],"genre_scores_gemma":[0.9990484,0.0001717921,0.0001204626,0.0001626217,0.0000275141,0.00006777709,0.0001619631,0.0000255236,0.0002139492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09833526,"threshold_uncertainty_score":0.9999924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295344755802724,"score_gpt":0.289100606666218,"score_spread":0.2761471591081907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}