{"id":"W2951132864","doi":"10.82308/15958","title":"Progranulin is expressed within motor neurons, promotes neuronal cell survival, and is secreted at least in part via the constitutive secretory pathway","year":2009,"lang":"en","type":"article","venue":"eScholarship@McGill (McGill)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University Health Centre","keywords":"Biology; Immunocytochemistry; Haploinsufficiency; Secretion; Cell biology; Molecular biology; Gene; Phenotype; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007380063,0.0002328166,0.00012763,0.0002642948,0.0001818129,0.0003100602,0.0001071846,0.0001821893,0.002401636],"category_scores_gemma":[0.0001088387,0.0000724056,0.0001160377,0.0001182179,0.0002541988,0.0001534081,0.0002519558,0.0002582294,0.001010048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004267242,"about_ca_system_score_gemma":0.000287332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004479,"about_ca_topic_score_gemma":0.001851831,"domain_scores_codex":[0.9999545,0.000007438555,0.000002236477,0.00001154077,0.00001394205,0.00001033054],"domain_scores_gemma":[0.9999529,0.000005297994,0.00001147853,0.000003663166,0.000008344442,0.00001837899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005113612,0.00000544481,0.0005789623,0.00005570558,0.000006585947,0.0005809471,0.00001840042,0.00003729215,0.9906977,0.000360971,0.0001979377,0.00740889],"study_design_scores_gemma":[0.00001929716,0.0002029748,0.02905525,0.00005537149,0.00002712759,0.005332597,0.0001180753,0.000426483,0.9223617,0.0005750582,0.04181467,0.00001128482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617869,0.01407297,0.005897653,0.0005392297,0.00008551681,0.00002845917,0.0008277211,0.0003205983,0.01644086],"genre_scores_gemma":[0.9706311,0.006249038,0.003945856,0.00009787689,0.0000236945,0.00002158578,0.0007900017,0.00003581392,0.01820512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002401636,"threshold_uncertainty_score":0.008034348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02795782043066686,"score_gpt":0.2463125981932649,"score_spread":0.218354777762598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}