{"id":"W2951161537","doi":"10.1021/ol040053b","title":"Tandem Functionalization of Nonactivated Alkenes and Alkynes in Intramolecular <i>N</i>-Acyloxyiminium Ion Carbocyclization. Synthesis of 6-Substituted Hydroindole 2-Carboxylic Acids","year":2004,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Enantiopure drug; Tandem; Intramolecular force; Surface modification; Carboxylic acid; Stille reaction; Combinatorial chemistry; Medicinal chemistry; Organic chemistry; Stereochemistry; Catalysis; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444007,0.0004917512,0.0002104572,0.0001070528,0.0001179261,0.000215295,0.000321969,0.000223443,0.001239169],"category_scores_gemma":[0.0001238857,0.0001527613,0.0001873512,0.0001184624,0.0001737289,0.000228755,0.000255489,0.0002548924,0.0005928413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212694,"about_ca_system_score_gemma":0.0002248376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004041961,"about_ca_topic_score_gemma":0.001027475,"domain_scores_codex":[0.9998927,0.00001514798,0.000007250391,0.00002207392,0.00002241245,0.00004036838],"domain_scores_gemma":[0.9999439,0.000006474604,0.00001992767,0.000006054986,0.000006686426,0.00001703141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008597011,0.00001468508,0.00005356017,0.00005158224,0.000005508243,0.0001323608,0.00002390227,0.000158836,0.9964762,0.000244332,0.00004556864,0.002707451],"study_design_scores_gemma":[0.00001591592,0.0001757266,0.0004302702,0.000002823921,0.000009256863,0.0001798659,0.000009476437,0.0002863709,0.9965648,0.00003304228,0.002287464,0.000004972318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729917,0.002628873,0.01243595,0.00008585015,0.00008494405,0.000105527,0.000212927,0.0002034494,0.0112508],"genre_scores_gemma":[0.9869704,0.00130188,0.007812859,0.00003838758,0.00001321903,0.00003784311,0.0002276662,0.000034394,0.00356339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239169,"threshold_uncertainty_score":0.004145443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005242525053388903,"score_gpt":0.1835088088076881,"score_spread":0.1782662837542992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}