{"id":"W2951193975","doi":"10.1101/218792","title":"Structure of transmembrane helix 8 and possible membrane defects in CFTR","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Canada Research Chairs; Cystic Fibrosis Trust; Alberta Innovates - Health Solutions; Alberta Innovates - Technology Futures; Compute Canada","keywords":"Cystic fibrosis transmembrane conductance regulator; Gating; ATP-binding cassette transporter; Biophysics; Transmembrane protein; Transmembrane domain; Chemistry; Transporter; Context (archaeology); Phosphorylation; Helix (gastropod); ATP hydrolysis; Membrane potential; Zebrafish; Cystic fibrosis; Biochemistry; Cell biology; Membrane; Biology; ATPase; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007656587,0.0002453124,0.0002002621,0.0001614497,0.0004950374,0.0002376962,0.0003362151,0.0006172848,0.001733965],"category_scores_gemma":[0.0002415403,0.0001454333,0.0002225528,0.0001486205,0.0003567854,0.000239622,0.0002419381,0.0005719575,0.0001977648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004638702,"about_ca_system_score_gemma":0.0002767766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002234632,"about_ca_topic_score_gemma":0.001480812,"domain_scores_codex":[0.9999609,0.000006253343,0.000001891598,0.000007942372,0.00001333107,0.000009611727],"domain_scores_gemma":[0.9999318,0.00001636003,0.00001747029,0.000004502841,0.000009261054,0.00002049398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001388097,0.0003297391,0.01763801,0.0003649199,0.0001336186,0.005994693,0.0005130259,0.1261181,0.8273183,0.008901975,0.003006142,0.008293432],"study_design_scores_gemma":[0.0006934906,0.001574782,0.0540758,0.0002279794,0.0001697974,0.002415602,0.0008478596,0.7377476,0.1821245,0.01139195,0.008552082,0.0001785748],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974971,0.0002133307,0.001241387,0.0001307323,0.00002009554,0.000005342494,0.0001024152,0.00003875878,0.0007507643],"genre_scores_gemma":[0.9987704,0.00005623051,0.0008369314,0.00002301632,0.000002811083,0.000004964799,0.0001221389,0.000006689773,0.0001767875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002234632,"threshold_uncertainty_score":0.005800664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354769034145378,"score_gpt":0.2641868082869465,"score_spread":0.2506391179454927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}