{"id":"W2951196122","doi":"10.1016/j.devcel.2019.05.021","title":"PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression","year":2019,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Institut de Recherche Clinique De Montréal","keywords":"PRC2; Chromatin; Biology; Enhancer; Hox gene; Gene silencing; Cell biology; Polycomb-group proteins; Regulation of gene expression; Gene; EZH2; Genetics; Gene expression; Repressor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003683576,0.0001451715,0.0001661573,0.00003655472,0.00006028402,0.00002076002,0.0003296365,0.0001499808,0.000006313756],"category_scores_gemma":[0.00004164154,0.0001010944,0.00005484001,0.0001063124,0.00001968057,0.000004590407,0.0001475885,0.00009661791,0.000005223995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007916932,"about_ca_system_score_gemma":0.0001942645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003047743,"about_ca_topic_score_gemma":0.0002368973,"domain_scores_codex":[0.9989759,0.00006101633,0.0003340927,0.0002381257,0.0001323237,0.0002585698],"domain_scores_gemma":[0.9995605,0.00005760713,0.0001457277,0.0001693353,0.00004383994,0.0000230352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008798988,0.0000857712,0.006856494,0.00002758319,0.00001272359,9.568956e-7,0.0006765252,0.00002492306,0.99185,0.0001846065,0.00005908372,0.0001333177],"study_design_scores_gemma":[0.001264152,0.0001562657,0.05605961,0.00006345747,0.000004057897,0.000006392989,0.00146093,0.0007992532,0.9390489,0.0005821164,0.0003623553,0.0001924442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983695,0.0001539635,0.0002169164,0.00007717637,0.00006559133,0.000741759,0.00001827909,0.000004025297,0.0003528064],"genre_scores_gemma":[0.9918259,0.00007697967,0.00747387,0.0002301084,0.00001801673,0.00008280709,0.0001361874,0.00001998897,0.0001361182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05280106,"threshold_uncertainty_score":0.4122511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006519864487247868,"score_gpt":0.2061842983167052,"score_spread":0.1996644338294573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}