{"id":"W2951199763","doi":"10.1002/chin.200239112","title":"Design and Synthesis of a Novel Class of Constrained Tricyclic Pyrrolizidinone Carboxylic Acids as Carbapenem Mimics.","year":2002,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis of β-Lactam Compounds","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Tricyclic; Combinatorial chemistry; Class (philosophy); Carbapenem; Organic chemistry; Antibiotics; Biochemistry; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002202081,0.0003474725,0.0007144934,0.0001494911,0.00005176669,0.00002448497,0.000450854,0.0003163827,0.000951401],"category_scores_gemma":[0.0007158894,0.0003497018,0.0001728458,0.0002357113,0.0004498824,0.0001536696,0.000118245,0.0001851236,0.00001074826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000930457,"about_ca_system_score_gemma":0.00008322583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005363365,"about_ca_topic_score_gemma":0.000001257993,"domain_scores_codex":[0.9981496,0.000001720349,0.0007231971,0.0003235839,0.0003947603,0.0004071887],"domain_scores_gemma":[0.9974237,0.001166549,0.0004635039,0.0006418292,0.0001263033,0.0001781201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001183901,0.0003579337,0.0002391357,0.0005062012,0.0002345555,0.000006592586,0.0007770142,0.000003529193,0.9463931,0.0001427213,0.000570471,0.05065038],"study_design_scores_gemma":[0.0013959,0.00003871587,0.00004949516,0.0001747162,0.0001484576,0.00009453079,0.0004384293,0.002649529,0.993597,0.00002422532,0.001057622,0.0003313534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5494736,0.0003529313,0.00001195252,0.0001233271,0.00003007251,0.0001359678,0.00003003568,0.00007338496,0.4497687],"genre_scores_gemma":[0.9964723,0.0001772138,0.001552249,0.00003882348,0.00005378526,0.00004560101,0.000004829274,0.0000463251,0.00160887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4481599,"threshold_uncertainty_score":0.9999619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02901868595461315,"score_gpt":0.227004700493548,"score_spread":0.1979860145389348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}