{"id":"W2951208009","doi":"10.1139/v02-035","title":"Baeyer-Villiger oxidations catalyzed by engineered microorganisms: Enantioselective synthesis of δ-valerolactones with functionalized chains","year":2002,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Enantioselective synthesis; Chemistry; Enantiopure drug; Stereochemistry; Yeast; Monooxygenase; Baeyer–Villiger oxidation; Cyclohexanone; Dihydroxylation; Biocatalysis; Comamonas; Organic chemistry; Catalysis; Pseudomonas; Bacteria; Enzyme; Biochemistry; Reaction mechanism; Cytochrome P450","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000178636,0.0005159811,0.0001912873,0.0001551898,0.00007052525,0.0002336336,0.0001699871,0.000198288,0.0004511831],"category_scores_gemma":[0.0001833248,0.0001379453,0.0001742842,0.0001676857,0.0001295626,0.0002333932,0.0001862663,0.0003345196,0.000255891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178948,"about_ca_system_score_gemma":0.0001436904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006109354,"about_ca_topic_score_gemma":0.001375785,"domain_scores_codex":[0.999882,0.00002675607,0.00001146566,0.00001995222,0.00003153089,0.00002824999],"domain_scores_gemma":[0.99994,0.0000151327,0.00001813255,0.000006873236,0.000008410566,0.00001137784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004562863,0.00001482078,0.0001090025,0.00002674289,0.000004887132,0.00004833561,0.00001738253,0.0001518621,0.9972057,0.0001341321,0.00001387774,0.002227611],"study_design_scores_gemma":[0.000005647471,0.00008515875,0.0002328667,0.000001697912,0.000004902679,0.00006223714,0.00001171906,0.0002232495,0.9988071,0.00002198306,0.0005409869,0.000002572624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819711,0.001540562,0.01449748,0.00008139443,0.00002346759,0.00004795132,0.0001634987,0.0001009683,0.001573628],"genre_scores_gemma":[0.9807241,0.001499345,0.01520732,0.00002554846,0.00000362379,0.00002479509,0.0002512347,0.00002277586,0.002241311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006109354,"threshold_uncertainty_score":0.001580954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004944915431813878,"score_gpt":0.1744108824116501,"score_spread":0.1694659669798362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}