{"id":"W2951257975","doi":"10.1002/chin.200321113","title":"Synthesis of 4‐Alkyl‐1,2‐diphenyl‐3,5‐dioxopyrazolidines Possessing Aryl Methylsulfonyl and Sulfonamide Pharmacophores for Evaluation as Selective Cyclooxygenase‐2 (COX‐2) Inhibitors.","year":2003,"lang":"en","type":"article","venue":"ChemInform","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Pharmacophore; Aryl; Sulfonamide; Alkyl; Cyclooxygenase; Combinatorial chemistry; Organic chemistry; Stereochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678037,0.0005541225,0.0003835059,0.0002372346,0.000194455,0.0002311782,0.0004763719,0.0002966795,0.004682498],"category_scores_gemma":[0.000169163,0.000264944,0.0001983042,0.0002179626,0.0001980554,0.0002825029,0.0002287201,0.0004659787,0.001402655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000326005,"about_ca_system_score_gemma":0.0007453077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005799424,"about_ca_topic_score_gemma":0.001861357,"domain_scores_codex":[0.999922,0.00001244254,0.000007417763,0.00001207047,0.00001482312,0.00003128143],"domain_scores_gemma":[0.9999416,0.000006509297,0.00001804723,0.000006436137,0.000008800311,0.00001870153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005949821,0.0002039604,0.0001046965,0.000672225,0.00002930974,0.0005238894,0.00009962769,0.00151333,0.9628919,0.002891955,0.001796285,0.028678],"study_design_scores_gemma":[0.0007828584,0.004493604,0.001877532,0.00006614871,0.00007752412,0.0009606942,0.00005845225,0.002086244,0.9422669,0.0007333523,0.04652337,0.00007334211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8626767,0.03029557,0.05441932,0.0011553,0.001023558,0.001303481,0.004659125,0.001195771,0.04327104],"genre_scores_gemma":[0.950358,0.01204251,0.02286126,0.0002290754,0.00007746887,0.0003815984,0.001621945,0.00005016643,0.01237786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004682498,"threshold_uncertainty_score":0.01566458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01443336298411381,"score_gpt":0.3043966142510233,"score_spread":0.2899632512669095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}