{"id":"W2951283659","doi":"10.1128/jvi.00614-19","title":"A Caulobacter crescentus Microbicide Protects from Vaginal Infection with HIV-1 <sub>JR-CSF</sub> in Humanized Bone Marrow-Liver-Thymus Mice","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Microbicides for sexually transmitted diseases; Vaginal microbicide; Microbicide; Biology; Humanized mouse; Human immunodeficiency virus (HIV); Immunology; Virology; Vagina; Medicine; Population; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004250248,0.0005085272,0.0003155596,0.0005200942,0.0001863785,0.0003700218,0.00039569,0.0004606186,0.000956622],"category_scores_gemma":[0.00016315,0.0002095959,0.0002707145,0.0001484272,0.0003878503,0.000206291,0.0001172533,0.0007051508,0.0002089983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000239384,"about_ca_system_score_gemma":0.0005542791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001901513,"about_ca_topic_score_gemma":0.003320036,"domain_scores_codex":[0.9997657,0.00004784929,0.00001387388,0.00003274323,0.00005826577,0.00008165655],"domain_scores_gemma":[0.9998288,0.00002587295,0.00004479244,0.00001868498,0.00001690784,0.00006481053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007753565,0.0005345905,0.000299514,0.00005959993,0.00001477345,0.00008104754,0.00002760409,0.0001544097,0.992314,0.0001246685,0.00009173308,0.005522574],"study_design_scores_gemma":[0.0002355423,0.0103742,0.003020185,0.00002073164,0.00003108908,0.0003033424,0.00003276188,0.0007297664,0.9832528,0.00004527564,0.001947858,0.000006496222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944245,0.002321546,0.00131032,0.0001529868,0.00005214892,0.00009765267,0.0002798699,0.00009441823,0.001266531],"genre_scores_gemma":[0.9916798,0.001952463,0.002734184,0.0001033383,0.00002407145,0.00007341534,0.0004341189,0.00002208992,0.002976371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001901513,"threshold_uncertainty_score":0.003780901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00845544199567711,"score_gpt":0.2335759099550777,"score_spread":0.2251204679594006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}