{"id":"W2951346584","doi":"10.1097/shk.0000000000001394","title":"Catecholamines Induce Endoplasmic Reticulum Stress Via Both Alpha and Beta Receptors","year":2019,"lang":"en","type":"article","venue":"Shock","topic":"Burn Injury Management and Outcomes","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Sunnybrook Hospital; University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Endoplasmic reticulum; Hypermetabolism; Prazosin; Endocrinology; Unfolded protein response; Internal medicine; Receptor; Propranolol; Adrenergic receptor; Catecholamine; Chemistry; Medicine; Biology; Cell biology; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032916,0.0001510629,0.000254041,0.000106212,0.00003984072,0.00002675639,0.00009000839,0.00008631939,0.0005022396],"category_scores_gemma":[0.00001897578,0.0001222501,0.00004930243,0.0001178397,0.00004188218,0.0001089053,0.00008751883,0.0001761917,0.0002221464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002344583,"about_ca_system_score_gemma":0.00001499333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005569802,"about_ca_topic_score_gemma":0.00002014787,"domain_scores_codex":[0.999124,0.00001920366,0.0001742075,0.0002659502,0.0001851013,0.0002315532],"domain_scores_gemma":[0.999487,0.00003596298,0.0000538451,0.000308754,0.00002686865,0.00008753069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001263753,0.00008812391,0.9560166,0.0003936528,0.0001776827,0.0000308042,0.0003702422,9.32482e-7,0.008526054,0.0007019741,0.01362195,0.01994558],"study_design_scores_gemma":[0.006350437,0.00123256,0.5883709,0.0005083346,0.0005073153,0.00008777381,0.001426454,0.0005712208,0.1444151,0.0006391503,0.25489,0.001000857],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848216,0.0002822701,0.00002423858,0.001399539,0.0006749709,0.0003997577,0.000003811002,0.0000856934,0.01230816],"genre_scores_gemma":[0.9704867,0.0001138763,0.0003149516,0.0004576493,0.0001324338,0.000004947246,0.00002921938,0.00002448602,0.02843573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3676458,"threshold_uncertainty_score":0.5499172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009973293974475408,"score_gpt":0.2471218537965481,"score_spread":0.2371485598220726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}