{"id":"W2951351778","doi":"10.1002/chin.200828114","title":"ChemInform Abstract: Efficient Preparation of the Isoindoline Framework via a Six Component, Tandem Double A<sup>3</sup>‐Coupling and [2 + 2 + 2] Cycloaddition Reaction.","year":2008,"lang":"en","type":"article","venue":"ChemInform","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Isoindoline; Tandem; Component (thermodynamics); Combinatorial chemistry; Coupling (piping); Cycloaddition; Coupling reaction; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534124,0.0004900376,0.0002716015,0.0004312013,0.0002649369,0.0002823631,0.0007161833,0.000268046,0.007357929],"category_scores_gemma":[0.0001310623,0.0002151432,0.0002541344,0.0003926104,0.0001499003,0.0004136318,0.0003776264,0.0006772504,0.004498369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751592,"about_ca_system_score_gemma":0.0006812558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006107436,"about_ca_topic_score_gemma":0.001325947,"domain_scores_codex":[0.9998866,0.00001341501,0.000007107794,0.0000254731,0.00003665476,0.00003055889],"domain_scores_gemma":[0.9999551,0.0000036153,0.00001018425,0.000006536588,0.00000964871,0.00001499427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004300543,0.0001386579,0.0001429596,0.0005809891,0.00004204683,0.0003898848,0.00008805668,0.0008699304,0.912169,0.004118741,0.006231317,0.07479829],"study_design_scores_gemma":[0.00009096976,0.0006313146,0.0007606693,0.00002379349,0.00003201948,0.0006408777,0.00002321726,0.001171551,0.9450794,0.0005370265,0.05097558,0.00003354454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5640258,0.01694912,0.2589923,0.00150665,0.0008686463,0.001358369,0.007645633,0.005722689,0.1429308],"genre_scores_gemma":[0.8748301,0.007969027,0.07517627,0.000386746,0.00009722628,0.0002800412,0.00393251,0.0003964305,0.03693154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007357929,"threshold_uncertainty_score":0.02461469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02136886502717081,"score_gpt":0.2723323208935866,"score_spread":0.2509634558664158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}