{"id":"W2951409668","doi":"10.1021/ol050393c","title":"Directed Ortho Metalation Methodology. The<i>N</i>,<i>N</i>-Dialkyl Aryl<i>O</i>-Sulfamate as a New Directed Metalation Group and Cross-Coupling Partner for Grignard Reagents","year":2005,"lang":"en","type":"article","venue":"Organic Letters","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Metalation; Chemistry; Aryl; Electrophile; Reagent; Medicinal chemistry; Aryne; Transmetalation; Coupling reaction; Grignard reagent; Stereochemistry; Combinatorial chemistry; Organic chemistry; Catalysis; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086498,0.000538151,0.0002172157,0.0002022848,0.0001587155,0.0001629557,0.0005039654,0.0002115745,0.002141658],"category_scores_gemma":[0.000111807,0.0001656036,0.0001903481,0.0001310898,0.0002370232,0.0002071313,0.000432066,0.000449367,0.001154818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117248,"about_ca_system_score_gemma":0.0003328641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004713731,"about_ca_topic_score_gemma":0.001457374,"domain_scores_codex":[0.99981,0.00003974664,0.00001449488,0.00005037087,0.00004677103,0.00003856037],"domain_scores_gemma":[0.9999446,0.000005055845,0.00001682219,0.00001482635,0.000009073318,0.000009643863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001388541,0.00005918165,0.0002807439,0.0002565275,0.00002273721,0.0001982242,0.00007164717,0.0002439774,0.98086,0.003590355,0.001196381,0.01308131],"study_design_scores_gemma":[0.00003928792,0.0005326914,0.0006256971,0.000007440561,0.0000242889,0.001085741,0.00001692055,0.0005189556,0.9781168,0.0002653102,0.01874992,0.00001707662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6822886,0.005993712,0.2255896,0.0007418375,0.0004492708,0.000606787,0.001285514,0.001987865,0.08105688],"genre_scores_gemma":[0.9338605,0.003539428,0.04255596,0.0004124542,0.00004736005,0.000184258,0.0007689638,0.0001264869,0.01850463],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002141658,"threshold_uncertainty_score":0.007164538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03313073007814935,"score_gpt":0.2913464208077433,"score_spread":0.2582156907295939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}