{"id":"W2951452242","doi":"10.1021/ol050075d","title":"Enantioselective Friedel−Crafts Alkylation Reactions Catalyzed by a Chiral Nonracemic <i>C</i><sub>2</sub>-Symmetric 2,2‘-Bipyridyl Copper(II) Complex","year":2005,"lang":"en","type":"article","venue":"Organic Letters","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Enantioselective synthesis; Catalysis; Friedel–Crafts reaction; Alkylation; Copper; Organic chemistry; Stereochemistry; Medicinal chemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002284607,0.000454811,0.0004466764,0.0005264609,0.0006402381,0.0001008276,0.0004169951,0.0002518396,0.00138219],"category_scores_gemma":[0.0002380709,0.0004886505,0.000256694,0.002667481,0.0001122146,0.0005092008,0.0001261091,0.000525572,0.000842037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009678137,"about_ca_system_score_gemma":0.0001160098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008030546,"about_ca_topic_score_gemma":0.00004994656,"domain_scores_codex":[0.9971175,0.0000552339,0.0006932656,0.00077408,0.000681742,0.0006781428],"domain_scores_gemma":[0.9983893,0.0001622205,0.0004208619,0.0006169407,0.0001459437,0.0002647466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002453651,0.0002243838,0.0001833594,0.00002222342,0.0002136927,0.00000492755,0.0003358342,0.0000570499,0.9298313,0.00003485279,0.06195355,0.007114283],"study_design_scores_gemma":[0.001450986,0.00001750707,0.0001865387,0.00001620969,0.0001732923,0.00005332393,0.000124898,0.00232648,0.9603736,0.00001175031,0.03468639,0.000579072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858146,0.0002454297,0.002084773,0.006278294,0.000151768,0.0002016184,0.0001472441,0.000419737,0.004656587],"genre_scores_gemma":[0.9945393,0.0001095084,0.0001773398,0.002512637,0.0004466249,0.00004831369,0.001537925,0.000104857,0.0005235375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03054225,"threshold_uncertainty_score":0.9999359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007741272849050158,"score_gpt":0.2111521095653553,"score_spread":0.2034108367163051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}