{"id":"W2951457160","doi":"10.1097/01.hs9.0000559376.17429.23","title":"PF291 A PHASE 1B/2 CLINICAL STUDY OF TARGETED IDH1 INHIBITION WITH IVOSIDENIB, IN COMBINATION WITH THE BCL‐2 INHIBITOR VENETOCLAX, FOR PATIENTS WITH IDH1‐MUTATED (MIDH1) MYELOID MALIGNANCIES","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Venetoclax; Ven; IDH1; Medicine; Tolerability; Internal medicine; Oncology; Refractory (planetary science); Myeloid; Myeloid leukemia; Gastroenterology; Leukemia; Adverse effect; Chronic lymphocytic leukemia; Chemistry; Biology; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001162511,0.001274765,0.0009637066,0.0003149405,0.0003679726,0.0007572612,0.0006568318,0.001188975,0.006579893],"category_scores_gemma":[0.0006674324,0.0004350432,0.0006848397,0.0002544973,0.0006730427,0.0006761894,0.0002939843,0.002692231,0.001283328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009001315,"about_ca_system_score_gemma":0.001899998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009327142,"about_ca_topic_score_gemma":0.002828615,"domain_scores_codex":[0.9996825,0.0001561679,0.00001153162,0.00005398264,0.00003426466,0.00006140953],"domain_scores_gemma":[0.9996147,0.00006042223,0.00006112619,0.00002281741,0.00003123908,0.0002096814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5491193,0.1121361,0.006138195,0.00149976,0.0008970769,0.0007584261,0.000457813,0.005767937,0.1358045,0.001120568,0.02809261,0.1582078],"study_design_scores_gemma":[0.5692559,0.3985191,0.009541267,0.0000734343,0.0002143779,0.00080543,0.00005518153,0.002516213,0.008415824,0.0005923302,0.009970111,0.00004086361],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733648,0.00422097,0.001689416,0.001559281,0.0002221953,0.006482721,0.005576728,0.0003542249,0.006529551],"genre_scores_gemma":[0.9751648,0.002150584,0.00361396,0.001484379,0.0001447172,0.003480522,0.00731452,0.00006584778,0.006580626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006579893,"threshold_uncertainty_score":0.022012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650303000590497,"score_gpt":0.3079110771014915,"score_spread":0.2914080470955865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}