{"id":"W2951457160","doi":"10.1097/01.hs9.0000559376.17429.23","title":"PF291 A PHASE 1B/2 CLINICAL STUDY OF TARGETED IDH1 INHIBITION WITH IVOSIDENIB, IN COMBINATION WITH THE BCL‐2 INHIBITOR VENETOCLAX, FOR PATIENTS WITH IDH1‐MUTATED (MIDH1) MYELOID MALIGNANCIES","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Venetoclax; Ven; IDH1; Medicine; Tolerability; Internal medicine; Oncology; Refractory (planetary science); Myeloid; Myeloid leukemia; Gastroenterology; Leukemia; Adverse effect; Chronic lymphocytic leukemia; Chemistry; Biology; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007025887,0.0003726215,0.000806548,0.0001570879,0.0001106505,0.00003713822,0.0001812269,0.0001917337,0.00009902704],"category_scores_gemma":[0.0001610714,0.0002139986,0.00007310937,0.001051376,0.0002644763,0.0002762097,0.00007768338,0.0005899632,0.00002127332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000477206,"about_ca_system_score_gemma":0.0009127735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002042691,"about_ca_topic_score_gemma":0.000586343,"domain_scores_codex":[0.9967034,0.0002555312,0.000760585,0.0006641327,0.001074096,0.0005422104],"domain_scores_gemma":[0.9972762,0.0004028892,0.0004438827,0.0006577076,0.001051257,0.0001680713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.0627798,0.0218297,0.8846546,0.001169869,0.0008450484,0.0002361829,0.005416804,0.0004508967,0.01416176,0.0001623786,0.004359453,0.00393348],"study_design_scores_gemma":[0.4447483,0.1551341,0.3274167,0.003455938,0.0008674199,0.00008333033,0.0264338,0.004841928,0.03410788,0.00008016949,0.001492648,0.001337838],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909205,0.00007462284,0.0002123132,0.000376126,0.00005993248,0.008103163,0.00004272061,0.00006764227,0.0001429682],"genre_scores_gemma":[0.9975165,0.000008966067,0.0008578945,0.0001588947,0.00007737512,0.0005656161,0.0002992396,0.0001014657,0.0004140426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5572379,"threshold_uncertainty_score":0.8726611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650303000590497,"score_gpt":0.3079110771014915,"score_spread":0.2914080470955865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}