{"id":"W2951467837","doi":"10.1101/350280","title":"Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; BC Cancer Agency; McMaster University; Jewish General Hospital; Canada's Michael Smith Genome Sciences Centre; McGill University; McGill University Health Centre; Princess Margaret Cancer Centre; University of Calgary; University Health Network; University of Toronto; University of British Columbia; Hospital for Sick Children; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institute of Mental Health; Hospital for Sick Children; Terry Fox Research Institute; National Cancer Institute; Entertainment Industry Foundation; University of Toronto; Stand Up To Cancer; Genome British Columbia; Canadian Cancer Society Research Institute; National Institutes of Health; Government of Canada; Ontario Institute for Cancer Research; Genome Canada; Government of Ontario; American Association for Cancer Research","keywords":"Medulloblastoma; Cerebellum; Biology; Sonic hedgehog; Stem cell; Population; Granule cell; Neuroscience; Progenitor cell; Nestin; Pathology; Neural stem cell; Cell biology; Cancer research; Central nervous system; Medicine; Dentate gyrus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004787,0.0001639805,0.0001924167,0.0004741276,0.0001672858,0.0004263214,0.0001418359,0.0002086954,0.001147405],"category_scores_gemma":[0.0002191738,0.0001481825,0.0001468096,0.000233411,0.0002766552,0.0001657765,0.0002595955,0.0003196159,0.0003724106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004504252,"about_ca_system_score_gemma":0.0003910897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002155132,"about_ca_topic_score_gemma":0.003642111,"domain_scores_codex":[0.9998608,0.000008870375,0.000006827706,0.00005024566,0.00004344329,0.00002988623],"domain_scores_gemma":[0.9997987,0.00003473694,0.00007754181,0.00001944031,0.00003296278,0.00003654676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000172846,0.00001270991,0.03025802,0.00004973035,0.00001429229,0.0007147057,0.0002495726,0.0003661726,0.9574887,0.001277406,0.0002257291,0.009170267],"study_design_scores_gemma":[0.00001232522,0.0001392313,0.4480703,0.00002896891,0.00004168655,0.003544048,0.0003979821,0.001387868,0.5366594,0.00106228,0.008637185,0.00001872085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918312,0.0006670349,0.004300707,0.00007572745,0.0000076698,0.000008901979,0.0009755192,0.0001651677,0.001968069],"genre_scores_gemma":[0.9942155,0.0006017252,0.002683217,0.00002957028,0.000006864876,0.00001322298,0.0009572457,0.00004824862,0.001444376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002155132,"threshold_uncertainty_score":0.004285157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454254272545267,"score_gpt":0.2331727285469056,"score_spread":0.218630185821453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}