{"id":"W2951480173","doi":"10.1139/v04-011","title":"Cyclization of 2-(2-bromoethoxy)-acetophenones and 5-(ω-haloalkoxy)-1,5-dihydro-2<i>H</i>-pyrrol-2-ones Formation of five- to eight-membered oxygen-containing heterocycles via intramolecular alkylation","year":2004,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Synthesis of Organic Compounds","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Lithium diisopropylamide; Lithium (medication); Alkylation; Sodium hydride; Intramolecular force; Medicinal chemistry; Hydride; Stereochemistry; Organic chemistry; Hydrogen; Catalysis; Ion","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008067107,0.0002444616,0.0000766868,0.0001629972,0.00008992425,0.0001028899,0.0001207437,0.0000916781,0.001942529],"category_scores_gemma":[0.00009229466,0.00008881442,0.0001319935,0.0001001511,0.0001324643,0.0001271367,0.000184288,0.0001850335,0.000387962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064038,"about_ca_system_score_gemma":0.0001964863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002699044,"about_ca_topic_score_gemma":0.0007358428,"domain_scores_codex":[0.9999393,0.000009131728,0.000003807636,0.00001028909,0.00001008823,0.00002734949],"domain_scores_gemma":[0.9999599,0.000007405781,0.000009536956,0.000006564225,0.000004884677,0.00001165536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001295152,0.00003283563,0.0003182434,0.00007759505,0.000009433172,0.0003287403,0.000121685,0.0003210268,0.9882982,0.000809908,0.00007853045,0.009474279],"study_design_scores_gemma":[0.00002466857,0.0004948511,0.002955049,0.000008354248,0.00001307966,0.0003960961,0.00003470654,0.0004520523,0.9903548,0.0001375814,0.005121794,0.0000070553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891774,0.0006868049,0.004187527,0.00005194544,0.00002405429,0.00003001825,0.0001051774,0.0000740389,0.005663093],"genre_scores_gemma":[0.995181,0.0004748543,0.001409938,0.0000211134,0.000005099878,0.00001767815,0.000123772,0.00001159631,0.002754923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001942529,"threshold_uncertainty_score":0.006498337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008317287529196611,"score_gpt":0.2186838915793485,"score_spread":0.2103666040501519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}