{"id":"W2951517287","doi":"10.1126/science.aau6323","title":"Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":741,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Life Sciences Research Foundation; Rheumatology Research Foundation; National Science Foundation; Damon Runyon Cancer Research Foundation; Howard Hughes Medical Institute; Bill and Melinda Gates Foundation; Arthritis Foundation; Natural Sciences and Engineering Research Council of Canada; David and Lucile Packard Foundation; National Institutes of Health; Kinship Foundation","keywords":"Aromatic L-amino acid decarboxylase; Gut flora; Enzyme; Metabolism; Drug metabolism; Biochemistry; Tyramine; Decarboxylation; Pharmacology; Microbial metabolism; Microbiology; Chemistry; Biology; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004046886,0.0005582072,0.000384626,0.0004088522,0.000241655,0.0007747872,0.0003031725,0.0007758107,0.001589912],"category_scores_gemma":[0.0002724649,0.0002531165,0.0005229446,0.0001963636,0.0003645294,0.0004641155,0.0006856792,0.001252861,0.0006942188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004967031,"about_ca_system_score_gemma":0.0004697521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003355079,"about_ca_topic_score_gemma":0.0007632286,"domain_scores_codex":[0.9997867,0.00003890639,0.00001246853,0.00003147949,0.00006659677,0.0000638334],"domain_scores_gemma":[0.9998858,0.00001736047,0.00002435622,0.0000124189,0.00002879819,0.00003121009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003519522,0.0002574932,0.0005030833,0.0003856016,0.00003356844,0.0003233556,0.00003925619,0.0002807514,0.943399,0.004527899,0.001327345,0.04857078],"study_design_scores_gemma":[0.0001665252,0.002212579,0.00343977,0.0001590411,0.00009803555,0.001009723,0.00009204749,0.002058803,0.8980451,0.001435302,0.09125165,0.00003129952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6872311,0.1767981,0.0646043,0.01271963,0.00293954,0.000903432,0.001072596,0.0007564019,0.05297493],"genre_scores_gemma":[0.8658323,0.08114824,0.03155064,0.002139642,0.0003226352,0.0003506199,0.0007031225,0.00009724633,0.01785554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001589912,"threshold_uncertainty_score":0.00531882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008079389117165521,"score_gpt":0.2540124681714624,"score_spread":0.2459330790542969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}