{"id":"W2951521848","doi":"10.1101/676601","title":"SKELETAL MyBP-C ISOFORMS TUNE THE MOLECULAR CONTRACTILITY OF DIVERGENT SKELETAL MUSCLE SYSTEMS","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; University of Vermont; American Heart Association","keywords":"Actin; Myosin; Gene isoform; Skeletal muscle; Biology; Sarcomere; Microfilament; Myofilament; Cell biology; Protein filament; Biophysics; Chemistry; Anatomy; Biochemistry; Myocyte; Cytoskeleton; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002031355,0.0002819531,0.0002252829,0.0002360582,0.0001364272,0.0002143929,0.0002291335,0.000202968,0.001054651],"category_scores_gemma":[0.000175441,0.0001598633,0.0001849254,0.0001365851,0.0002331472,0.0001550756,0.0002453622,0.000330002,0.0003426508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002867311,"about_ca_system_score_gemma":0.0001115637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005484018,"about_ca_topic_score_gemma":0.0007138906,"domain_scores_codex":[0.999878,0.00001474047,0.00001026445,0.00003509332,0.00002841787,0.00003342585],"domain_scores_gemma":[0.9998251,0.00002953949,0.0000379001,0.00001868513,0.00003532472,0.00005353463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003911327,0.000003155478,0.0002009966,0.00000559913,0.000001177408,0.000008218611,0.00000340629,0.000008019487,0.9995185,0.00001523872,0.000004571184,0.0001920061],"study_design_scores_gemma":[0.00003642005,0.0002478293,0.08351353,0.00001619855,0.00002783287,0.000306424,0.00008123092,0.001649332,0.9126971,0.0001008317,0.001312212,0.00001100101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976792,0.0003303709,0.001222264,0.00003020176,0.000007733512,0.00001178198,0.0001811981,0.00002199917,0.000515305],"genre_scores_gemma":[0.9959955,0.0002517211,0.001827525,0.00005049837,0.000006553164,0.00002577242,0.000374571,0.00001887377,0.001449046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054651,"threshold_uncertainty_score":0.003528118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226744426409911,"score_gpt":0.2278760281208431,"score_spread":0.2156085838567439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}