{"id":"W2951540630","doi":"10.3390/cancers11060813","title":"Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"University Research Committee, University of Hong Kong","keywords":"Homeobox protein NANOG; Cancer research; Ovarian cancer; Metastasis; Biology; Cancer cell; MMP9; Intravasation; Cancer stem cell; Cell migration; Cancer; Stem cell; Embryonic stem cell; Cell biology; Cell; Downregulation and upregulation; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457821,0.0002439733,0.0002570343,0.00004204763,0.0001221068,0.00005156217,0.000160953,0.000212888,0.0001697416],"category_scores_gemma":[0.00001273603,0.0002348451,0.00008813831,0.0001129142,0.00008247484,0.00002045768,0.00007648639,0.00009906942,0.00000801177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001758283,"about_ca_system_score_gemma":0.0004375668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00431603,"about_ca_topic_score_gemma":0.003464936,"domain_scores_codex":[0.998648,0.00005170605,0.0002424886,0.0005609443,0.000161264,0.0003355897],"domain_scores_gemma":[0.9991956,0.00001305254,0.0001418118,0.0003747418,0.0001215253,0.0001532174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001213769,0.000009935411,0.001782383,0.0001153353,0.00004914317,0.000001182868,0.0003455011,0.001293545,0.9861649,0.00002551761,0.004423797,0.005667415],"study_design_scores_gemma":[0.001158289,0.0001076732,0.001501288,0.00007442277,0.00006574567,0.00001104609,0.0003944801,0.0002940779,0.7744553,0.00004820327,0.2214953,0.0003941813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683858,0.02868796,0.0002471168,0.0001307911,0.00159813,0.0003618125,0.00006144033,0.00002025463,0.000506672],"genre_scores_gemma":[0.9875627,0.006640099,0.0001942494,0.0004633459,0.001216074,0.00007076877,0.00009232345,0.00004396226,0.00371651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2170715,"threshold_uncertainty_score":0.9576704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007736962128583256,"score_gpt":0.2236137978210963,"score_spread":0.215876835692513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}