{"id":"W2951540630","doi":"10.3390/cancers11060813","title":"Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"University Research Committee, University of Hong Kong","keywords":"Homeobox protein NANOG; Cancer research; Ovarian cancer; Metastasis; Biology; Cancer cell; MMP9; Intravasation; Cancer stem cell; Cell migration; Cancer; Stem cell; Embryonic stem cell; Cell biology; Cell; Downregulation and upregulation; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000071028,0.0002265581,0.0001334017,0.0001327824,0.0001299433,0.0002707103,0.00006006368,0.0001048797,0.001108682],"category_scores_gemma":[0.00005348924,0.00008416706,0.0001922715,0.0001273892,0.0001157534,0.0001480208,0.0001334494,0.0002910291,0.0001247823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00025586,"about_ca_system_score_gemma":0.00023758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009711332,"about_ca_topic_score_gemma":0.001674518,"domain_scores_codex":[0.9999385,0.000007993332,0.000005335066,0.0000103634,0.00001469661,0.00002311922],"domain_scores_gemma":[0.999975,0.000001864669,0.000008350716,0.000001717237,0.0000046044,0.000008495352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007919497,0.00007266543,0.005430465,0.0002257092,0.00003148672,0.0001816988,0.00006626517,0.00036818,0.9833546,0.0005440246,0.0005236937,0.008409119],"study_design_scores_gemma":[0.0001196617,0.0004291793,0.102328,0.00002060672,0.00009936663,0.0004432385,0.0002567703,0.006264023,0.8789421,0.0003388541,0.01073643,0.00002171894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890364,0.004436881,0.002549089,0.0002733667,0.00007463679,0.00003892762,0.0007159999,0.0001107221,0.002763992],"genre_scores_gemma":[0.9957877,0.001147093,0.0005930644,0.00004424161,0.000007625096,0.00002261874,0.0002923211,0.000004749889,0.002100693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108682,"threshold_uncertainty_score":0.003708899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007736962128583256,"score_gpt":0.2236137978210963,"score_spread":0.215876835692513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}