{"id":"W2951568116","doi":"10.1021/jo991571g","title":"Design and Synthesis of Novel Thiazole-Containing Cross-Linked Polyamides Related to the Antiviral Antibiotic Distamycin","year":2000,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta","keywords":"Netropsin; Thiazole; Stereochemistry; Polyamide; DNA; Chemistry; Monomer; Ring (chemistry); Amidine; DNA gyrase; Biochemistry; Organic chemistry; Gene; Polymer; Minor groove","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007821626,0.000186476,0.000253608,0.00001133417,0.0001323164,0.0000330877,0.0005405055,0.0001644032,0.0001520174],"category_scores_gemma":[0.0002826174,0.0001157087,0.00009579129,0.0001276504,0.000240919,0.000008792329,0.000103819,0.0002545816,0.000002958105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001845076,"about_ca_system_score_gemma":0.000104526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003797,"about_ca_topic_score_gemma":5.043447e-7,"domain_scores_codex":[0.9988855,0.0000513537,0.0004793,0.0001625471,0.0001986422,0.0002226609],"domain_scores_gemma":[0.9990002,0.0001253184,0.000299394,0.000388055,0.0001011904,0.00008587012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000443361,0.00007533211,0.0006960793,0.00003435501,0.0001293832,0.000004148372,0.0002150127,0.0001189462,0.9962475,6.500057e-7,0.0001818282,0.001853411],"study_design_scores_gemma":[0.0006689689,0.0001048814,0.001582361,0.000094223,0.0001088819,0.0004512105,0.0003032923,0.00007386175,0.9961373,0.00001174067,0.0003194667,0.0001438707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973964,0.0007347343,0.0005460316,0.0004609097,0.00003730525,0.00007946508,0.000008632547,0.000005644693,0.0007308874],"genre_scores_gemma":[0.9982099,0.0003787091,0.0004564679,0.00009432663,0.0001291101,5.442656e-7,0.000002707009,0.00002909502,0.0006991525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00170954,"threshold_uncertainty_score":0.4718465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007714264667729197,"score_gpt":0.233250630420953,"score_spread":0.2255363657532238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}