{"id":"W2951568975","doi":"10.1021/jm0010264","title":"Antimitotic Antitumor Agents: Synthesis, Structure−Activity Relationships, and Biological Characterization of <i>N</i>-Aryl-<i>N</i>‘-(2-chloroethyl)ureas as New Selective Alkylating Agents","year":2001,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise","funders":"","keywords":"Chemistry; Cytotoxicity; Glutathione; Moiety; Aryl; Stereochemistry; Alkylation; Tubulin; In vivo; Biological activity; Structure–activity relationship; Urea; Alkyl; In vitro; Biochemistry; Microtubule; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003377576,0.0002951871,0.000566352,0.00004719207,0.0001903502,0.00002962715,0.0002982554,0.0003228004,0.001013677],"category_scores_gemma":[0.00201652,0.0002587406,0.0001447993,0.0002890737,0.0002027489,0.0002177568,0.00006777864,0.0009042555,0.000001804009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001100801,"about_ca_system_score_gemma":0.0002789017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002546668,"about_ca_topic_score_gemma":9.034026e-7,"domain_scores_codex":[0.9980537,0.000028909,0.0007999963,0.0003272708,0.0005062881,0.0002837877],"domain_scores_gemma":[0.9973202,0.0004487193,0.001280469,0.0002720102,0.0002441869,0.000434457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002795287,0.0001672082,0.04839258,0.000211646,0.0001049717,0.00005783175,0.000151307,0.00001114549,0.9476351,0.000008205167,0.0002769555,0.002703479],"study_design_scores_gemma":[0.0008059611,0.00004712595,0.03211087,0.0005176494,0.0002041031,0.001672482,0.0003358225,0.0001423728,0.9626273,0.0003704758,0.0009351533,0.0002306943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964095,0.0002290781,0.0003296224,0.0007186489,0.00005430212,0.00006714786,0.00004451781,0.00002570433,0.002121455],"genre_scores_gemma":[0.997916,0.0006657029,0.000200936,0.00007089714,0.0008164833,0.000003690469,0.00004917314,0.00002370156,0.0002534211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01628171,"threshold_uncertainty_score":0.9999865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03482890372449374,"score_gpt":0.2786343615889365,"score_spread":0.2438054578644427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}