{"id":"W2951568975","doi":"10.1021/jm0010264","title":"Antimitotic Antitumor Agents: Synthesis, Structure−Activity Relationships, and Biological Characterization of <i>N</i>-Aryl-<i>N</i>‘-(2-chloroethyl)ureas as New Selective Alkylating Agents","year":2001,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise","funders":"","keywords":"Chemistry; Cytotoxicity; Glutathione; Moiety; Aryl; Stereochemistry; Alkylation; Tubulin; In vivo; Biological activity; Structure–activity relationship; Urea; Alkyl; In vitro; Biochemistry; Microtubule; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002129712,0.0003581337,0.0003200666,0.0002641887,0.0001332355,0.0001541879,0.0002331041,0.0002053577,0.0006458702],"category_scores_gemma":[0.0001613983,0.0001244496,0.0001278608,0.0001747982,0.0001277371,0.0001775295,0.0001410929,0.0003042969,0.0002042678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002458988,"about_ca_system_score_gemma":0.0002533341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004115216,"about_ca_topic_score_gemma":0.001978562,"domain_scores_codex":[0.999922,0.00001688125,0.000008035467,0.00001197016,0.00002249819,0.00001864433],"domain_scores_gemma":[0.9999182,0.00001025892,0.00001964829,0.000006854698,0.0000217468,0.00002333069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001226101,0.00009707606,0.00021317,0.0001119775,0.000004870659,0.00006495487,0.00002217215,0.00025829,0.990867,0.0001657993,0.00006072681,0.008011355],"study_design_scores_gemma":[0.00004506266,0.001568747,0.001777572,0.000009861177,0.00001668844,0.0002234763,0.000009630089,0.0004926479,0.9921131,0.00002633741,0.003711295,0.000005636338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830526,0.008763644,0.004112874,0.00008290084,0.00001903629,0.0001795974,0.0002649191,0.0000874716,0.003436933],"genre_scores_gemma":[0.9776533,0.007651741,0.01019301,0.0001058758,0.00002147205,0.0001497057,0.0007342223,0.00001651442,0.003474337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006458702,"threshold_uncertainty_score":0.002160668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03482890372449374,"score_gpt":0.2786343615889365,"score_spread":0.2438054578644427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}