{"id":"W2951642517","doi":"10.1002/pbc.27888","title":"Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy","year":2019,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Johns Hopkins University","keywords":"Medicine; Ewing's sarcoma; Sarcoma; Cancer research; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143438,0.0001169385,0.0001428169,0.00009779165,0.00001841307,0.00001108087,0.00008106326,0.0001180295,0.00005644582],"category_scores_gemma":[0.00001154275,0.0001159716,0.00006204902,0.0002429006,0.00001882675,0.000004529832,0.00004412136,0.00008201085,0.00001337253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001502885,"about_ca_system_score_gemma":0.0001729848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003654557,"about_ca_topic_score_gemma":0.0000736029,"domain_scores_codex":[0.9990802,0.00003273189,0.0002558558,0.0002805285,0.0001582476,0.0001924179],"domain_scores_gemma":[0.9995342,0.00001222848,0.00012311,0.0002212056,0.0000688448,0.00004042203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006070421,0.0003319268,0.3495198,0.0001757176,0.00004685562,0.000002441723,0.0002795827,0.001258231,0.6408234,0.00009177947,0.00003439088,0.007375128],"study_design_scores_gemma":[0.001739852,0.0007091005,0.08601827,0.00002950569,0.0001351438,0.000001905193,0.00009432386,0.0002106673,0.9094239,0.0004595769,0.0008763797,0.0003013746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787264,0.01978626,0.00003245757,0.00004366888,0.0001197818,0.0002583071,0.00001955182,0.000004568979,0.001008942],"genre_scores_gemma":[0.9962012,0.003217041,0.00002937194,0.0001071064,0.0001990897,0.00003410631,0.00003513585,0.00001721348,0.000159797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2686005,"threshold_uncertainty_score":0.4729185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140133378969647,"score_gpt":0.2685272301149198,"score_spread":0.2571258963252233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}