{"id":"W2951642517","doi":"10.1002/pbc.27888","title":"Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy","year":2019,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Johns Hopkins University","keywords":"Medicine; Ewing's sarcoma; Sarcoma; Cancer research; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002586041,0.0003053673,0.0004494778,0.0001525666,0.0001143237,0.0003146563,0.0002663392,0.0002730672,0.001877745],"category_scores_gemma":[0.0001665633,0.0001031724,0.0002922977,0.0001539944,0.0002522735,0.0002375249,0.0001663072,0.0006758686,0.0004379412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003731204,"about_ca_system_score_gemma":0.0003662778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002614582,"about_ca_topic_score_gemma":0.000607817,"domain_scores_codex":[0.9998878,0.00001780507,0.00001277007,0.00002650831,0.00003282227,0.00002231387],"domain_scores_gemma":[0.9999169,0.00001935265,0.00002211689,0.00001707285,0.000008863422,0.00001565997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003563901,0.0001345186,0.0007131631,0.0003391243,0.00003712187,0.0001415635,0.00001998271,0.0005379853,0.9735439,0.0007919034,0.0004797725,0.02290463],"study_design_scores_gemma":[0.0001033865,0.001533998,0.004336635,0.0000346548,0.00009900662,0.001159817,0.00003532641,0.001244706,0.9674267,0.000310127,0.02370694,0.000008767146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.942649,0.03929933,0.006827406,0.0009452474,0.0002527699,0.0001620532,0.0006631335,0.0003711937,0.008829908],"genre_scores_gemma":[0.9876112,0.008202009,0.001825603,0.000135194,0.00001872978,0.00005285081,0.0004461289,0.00001920804,0.001688962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001877745,"threshold_uncertainty_score":0.006281734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140133378969647,"score_gpt":0.2685272301149198,"score_spread":0.2571258963252233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}