{"id":"W2951649327","doi":"10.2174/157019309789371659","title":"Intrinsically Fluorescent Base-Discriminating Nucleoside Analogs","year":2009,"lang":"en","type":"article","venue":"Mini-Reviews in Organic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Fluorophore; Nucleic acid; Computational biology; DNA; Nucleoside; Fluorescence; Aptamer; Ribozyme; Chemistry; Biology; Combinatorial chemistry; Biochemistry; Genetics; RNA; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003868135,0.0003940391,0.0004751706,0.00002478982,0.00007416849,0.00003740341,0.000586996,0.0003280112,0.001302941],"category_scores_gemma":[0.0006236309,0.000384228,0.0002007797,0.0002446546,0.00009494431,0.000007604656,0.0001892411,0.000339352,0.00006332888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008287963,"about_ca_system_score_gemma":0.00009604666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003976244,"about_ca_topic_score_gemma":0.000007165366,"domain_scores_codex":[0.9977701,0.00004799619,0.0007143384,0.0007397939,0.0002063833,0.0005214284],"domain_scores_gemma":[0.998659,0.00001703318,0.0002080766,0.0008517767,0.00005933746,0.0002047935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002566576,0.0001974019,0.0004346338,0.0001327152,0.00001258874,0.00002606581,0.00004769698,7.938835e-7,0.9526358,0.000005363554,0.007429918,0.03905136],"study_design_scores_gemma":[0.0006851996,0.00006816955,0.000966861,0.0001936714,0.00003073737,0.00006863662,0.00008781468,0.00002180475,0.8977214,0.00005825601,0.09962571,0.0004717745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784847,0.006199149,0.0001183029,0.0007605929,0.00009983625,0.000249213,0.00001162309,0.0000450209,0.01403154],"genre_scores_gemma":[0.9912844,0.002417599,0.001879521,0.001348585,0.0006098777,0.00002031122,0.000205741,0.00005133514,0.002182632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09219579,"threshold_uncertainty_score":0.9998609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101774280835469,"score_gpt":0.24693809116524,"score_spread":0.2367606630816931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}