{"id":"W2951657228","doi":"10.1165/rcmb.2019-0094oc","title":"Augmentation of Cystic Fibrosis Transmembrane Conductance Regulator Function in Human Bronchial Epithelial Cells via SLC6A14-Dependent Amino Acid Uptake. Implications for Treatment of Cystic Fibrosis","year":2019,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Regulator; Fibrosis; Transmembrane protein; Function (biology); Amino acid; Cell biology; Conductance; Cancer research; Chemistry; Pathology; Medicine; Biology; Internal medicine; Biochemistry; Gene; Receptor; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003449566,0.0002237671,0.0005012156,0.0001483098,0.0001861205,0.0002740583,0.0001822588,0.0003530103,0.001393125],"category_scores_gemma":[0.0001808442,0.0001032378,0.0003945894,0.0001784055,0.0001860014,0.000162663,0.000200122,0.0003534105,0.0004930184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001558188,"about_ca_system_score_gemma":0.0001513131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006373109,"about_ca_topic_score_gemma":0.0007443056,"domain_scores_codex":[0.9996696,0.0001304526,0.00003376667,0.00003949957,0.0000843011,0.00004252157],"domain_scores_gemma":[0.9998727,0.00003731237,0.00001601302,0.00002341046,0.00002914394,0.00002139635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009196493,0.00002239903,0.00009012168,0.00004270266,0.000002214816,0.00003676758,0.00001175446,0.00001257607,0.9987653,0.00001888401,0.00003089183,0.0008744391],"study_design_scores_gemma":[0.00003458871,0.001052917,0.008773967,0.00001093576,0.00001992537,0.0004290866,0.00005780362,0.0007370826,0.9837682,0.00002684101,0.005082335,0.000006342298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887793,0.005621512,0.002393077,0.0004050833,0.000104438,0.0001040692,0.0006389962,0.0001293871,0.001824103],"genre_scores_gemma":[0.9900976,0.002216265,0.004329305,0.0001234844,0.00002704918,0.00009145289,0.001022886,0.00002638808,0.002065632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001393125,"threshold_uncertainty_score":0.004660487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01185851864834417,"score_gpt":0.2964126294864727,"score_spread":0.2845541108381285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}