{"id":"W2951679150","doi":"10.1101/344952","title":"Synergistic Recruitment of UbcH7~Ub and Phosphorylated Ubl Domain Triggers Parkin Activation","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Parkin; Ubiquitin; Ubiquitin ligase; PINK1; Phosphorylation; Cell biology; Chemistry; Conjugate; Deubiquitinating enzyme; Cysteine; Ubiquitin-Protein Ligases; Biochemistry; Biology; Parkinson's disease; Medicine; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000153516,0.0001935607,0.0002228313,0.0001176369,0.0002407034,0.000367881,0.000189302,0.0002909229,0.003358683],"category_scores_gemma":[0.000158793,0.0001563153,0.0001774215,0.00009318733,0.0002353318,0.0002299505,0.0005540615,0.0004712979,0.0007844592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000458685,"about_ca_system_score_gemma":0.0001652057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004530702,"about_ca_topic_score_gemma":0.0007875159,"domain_scores_codex":[0.9998088,0.0000243869,0.000006480092,0.00003355122,0.0000492227,0.00007757545],"domain_scores_gemma":[0.9998853,0.00001700121,0.00001672645,0.00001118409,0.00000634577,0.00006343582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000400221,0.0000544758,0.0003895299,0.00004083646,0.000008444925,0.000378099,0.00002860256,0.0001723175,0.9970623,0.0002717325,0.0002957588,0.0008977235],"study_design_scores_gemma":[0.00004783431,0.0001486631,0.008181484,0.000007400288,0.00000728817,0.000316008,0.00007916,0.003809123,0.9843875,0.0002047978,0.002802136,0.000008572703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955212,0.0003847896,0.00111069,0.0001401984,0.00003063841,0.00001698223,0.0001412984,0.00009531897,0.002558849],"genre_scores_gemma":[0.9970508,0.00008446604,0.0006189998,0.00005490123,0.000006294375,0.00001328707,0.0001405817,0.00001154275,0.00201919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003358683,"threshold_uncertainty_score":0.01123595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02266361528396305,"score_gpt":0.2400185491346761,"score_spread":0.217354933850713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}