{"id":"W2951699133","doi":"10.1021/acsmedchemlett.9b00094","title":"High Affinity Fluorescent Probe for Proteinase-Activated Receptor 2 (PAR2)","year":2019,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Fluorophore; Fluorescence; In vivo; Peptide; Receptor; In vitro; Chemistry; G protein-coupled receptor; Biophysics; EC50; Conjugated system; Combinatorial chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002536258,0.0002752869,0.00047732,0.00004085533,0.0000768788,0.00001754518,0.0001586886,0.0001754433,0.00110161],"category_scores_gemma":[0.0001301352,0.0002381861,0.0001221425,0.0001823847,0.00007848351,0.00007485477,0.00004063201,0.0003430726,0.0001074492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001441772,"about_ca_system_score_gemma":0.0001097017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002681772,"about_ca_topic_score_gemma":3.652727e-7,"domain_scores_codex":[0.9982386,0.00002344476,0.0003549848,0.0004720567,0.0004966272,0.0004143147],"domain_scores_gemma":[0.998888,0.00006665762,0.0001761334,0.0004714942,0.0001381779,0.0002595285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004732533,0.0001922826,0.0003703061,0.0007029255,0.0001163836,0.000009268963,0.00009150904,0.000002439666,0.9928511,0.0001299397,0.004535713,0.0005248954],"study_design_scores_gemma":[0.004021289,0.000221757,0.0008999849,0.0003806917,0.0001324688,0.0000321422,0.0001268066,0.00002783027,0.9885215,0.0000592798,0.005329797,0.000246448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768231,0.00002877234,0.0008222617,0.01975521,0.0003928548,0.001643281,0.00001708458,0.0001710434,0.0003464256],"genre_scores_gemma":[0.9903635,0.000006629035,0.003632789,0.004218786,0.0006100867,0.000196399,0.0003312019,0.00005129469,0.0005893116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01553643,"threshold_uncertainty_score":0.9998115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696580829855097,"score_gpt":0.2478344270613251,"score_spread":0.2308686187627741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}