{"id":"W2951699133","doi":"10.1021/acsmedchemlett.9b00094","title":"High Affinity Fluorescent Probe for Proteinase-Activated Receptor 2 (PAR2)","year":2019,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Fluorophore; Fluorescence; In vivo; Peptide; Receptor; In vitro; Chemistry; G protein-coupled receptor; Biophysics; EC50; Conjugated system; Combinatorial chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000275423,0.0005088646,0.0003880927,0.0002223502,0.0002500825,0.0002454327,0.0004283952,0.0006633094,0.002275018],"category_scores_gemma":[0.0001508006,0.0001740214,0.0002990647,0.0001969192,0.0002441271,0.0003323393,0.0003376566,0.0008261033,0.000583269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004567816,"about_ca_system_score_gemma":0.0001943904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004446446,"about_ca_topic_score_gemma":0.0005657533,"domain_scores_codex":[0.9998147,0.00004972889,0.000007030726,0.00004124581,0.00003498948,0.00005226624],"domain_scores_gemma":[0.9998993,0.00002809355,0.00002175855,0.000008567508,0.00001678112,0.00002546827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007430579,0.00003618634,0.00006057177,0.00008649291,0.0000090024,0.00005638774,0.00001879535,0.000141089,0.9960917,0.0002274477,0.0002973663,0.002900633],"study_design_scores_gemma":[0.00003137062,0.0005902508,0.0005803856,0.000005226118,0.00001673114,0.0005190629,0.00001264668,0.0005554599,0.992671,0.0000358559,0.004971993,0.00001007609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9025429,0.01537017,0.06666993,0.0009478274,0.0001872002,0.0002612842,0.0006700201,0.0004436565,0.01290707],"genre_scores_gemma":[0.9477577,0.004536732,0.0396372,0.0005826202,0.00007309663,0.0001962663,0.0006499133,0.00003574519,0.00653077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002275018,"threshold_uncertainty_score":0.007610679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696580829855097,"score_gpt":0.2478344270613251,"score_spread":0.2308686187627741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}