{"id":"W2951706059","doi":"10.1183/13993003.00174-2018","title":"IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis","year":2019,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Health and Medical Research Council; National Institutes of Health; Australian Research Council; Wellcome Trust; Teva Pharmaceutical Industries; Regeneron Pharmaceuticals; Medical Research Council; Hunter Medical Research Institute; Sanofi; GlaxoSmithKline; AstraZeneca","keywords":"Medicine; Pathogenesis; COPD; Receptor; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003622206,0.0004161859,0.0004953811,0.0006054721,0.0001977176,0.0006595819,0.000153945,0.0006393709,0.001817432],"category_scores_gemma":[0.0004700925,0.0001716987,0.0002785393,0.0003371776,0.0004303983,0.0002447349,0.0003244139,0.0006732572,0.0005044905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392197,"about_ca_system_score_gemma":0.000240214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002540888,"about_ca_topic_score_gemma":0.0002324593,"domain_scores_codex":[0.9994032,0.0001769628,0.00004073522,0.00009028699,0.0002087919,0.00007987869],"domain_scores_gemma":[0.9996859,0.00003865579,0.0001111691,0.00003203804,0.00005541419,0.00007678889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002049122,0.0002383276,0.02203483,0.0006235469,0.0001102322,0.001319233,0.0001563106,0.0001606893,0.9463138,0.0005640155,0.0007559586,0.02567397],"study_design_scores_gemma":[0.0002189758,0.003709783,0.5792867,0.0003374997,0.0004614117,0.01518824,0.0007156472,0.001550085,0.3453796,0.002230714,0.05083559,0.00008578816],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9143988,0.07499681,0.003853382,0.0007945654,0.0001912726,0.0000915926,0.0007653838,0.0001879718,0.004720105],"genre_scores_gemma":[0.9865295,0.009483656,0.001222226,0.0002835721,0.0001562253,0.00008654278,0.0003756856,0.0000197126,0.001842926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001817432,"threshold_uncertainty_score":0.006079912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02202330139567347,"score_gpt":0.2937051561644213,"score_spread":0.2716818547687478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}