{"id":"W2951844788","doi":"10.1093/ndt/gfz103.sp345","title":"SP345ACTIVATION OF THE FREE-FATTY ACID RECEPTOR GPR40 IMPROVES ANEMIA IN MOUSE MODELS OF KIDNEY DISEASE VIA A NOVEL EPO-INDEPENDENT MECHANISM OF ACTION","year":2019,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"","keywords":"Medicine; Free fatty acid receptor 1; Mechanism of action; Mechanism (biology); Kidney; Anemia; Fatty acid; Receptor; Kidney disease; Disease; Endocrinology; Internal medicine; Biochemistry; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002639926,0.000529205,0.0004573391,0.0004010022,0.0001652648,0.0003351453,0.0003893169,0.0005499908,0.003291685],"category_scores_gemma":[0.0001032971,0.0001953144,0.0004584446,0.0002052467,0.0003600416,0.0003491461,0.0002757677,0.001281601,0.0006306148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002290415,"about_ca_system_score_gemma":0.0003024384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004095122,"about_ca_topic_score_gemma":0.000617353,"domain_scores_codex":[0.9997876,0.00003207524,0.00002116969,0.0000403872,0.00005466812,0.00006405184],"domain_scores_gemma":[0.9998935,0.00000756442,0.00003477046,0.00000989681,0.00001246925,0.00004166785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001089743,0.0001735521,0.0002083476,0.0001381952,0.00002196625,0.0000661774,0.00002105691,0.000131426,0.9933449,0.0002281659,0.000268921,0.004307527],"study_design_scores_gemma":[0.0003160833,0.004495267,0.004553863,0.00003554005,0.0001186248,0.000342527,0.00007917637,0.001141807,0.9797625,0.0002070643,0.008930597,0.00001692786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856219,0.003158518,0.005807946,0.0005607257,0.000145071,0.0001164327,0.001631441,0.0004382381,0.002519777],"genre_scores_gemma":[0.9847499,0.002677234,0.004905888,0.0002529395,0.00003507304,0.000200096,0.001387141,0.00004762656,0.005744099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003291685,"threshold_uncertainty_score":0.01101184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134236496081392,"score_gpt":0.2317259654900517,"score_spread":0.2203836005292378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}