{"id":"W2951870339","doi":"10.1002/chin.201640268","title":"ChemInform Abstract: Host—Guest Chemistry that Directly Targets Lysine Methylation: Synthetic Host Molecules as Alternatives to Bio‐Reagents","year":2016,"lang":"en","type":"article","venue":"ChemInform","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Chemistry; Host (biology); Methylation; Reagent; Lysine; Molecule; Combinatorial chemistry; Nanotechnology; Organic chemistry; Amino acid; Biochemistry; DNA; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007397023,0.001240059,0.0005812681,0.001534643,0.000445963,0.001417993,0.001017957,0.001603747,0.02805324],"category_scores_gemma":[0.0007546134,0.0005070816,0.0003326426,0.00184048,0.0008268452,0.001704569,0.001038734,0.002812006,0.02093283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001271097,"about_ca_system_score_gemma":0.0009538329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007829063,"about_ca_topic_score_gemma":0.001313572,"domain_scores_codex":[0.9997038,0.00003973574,0.00001934487,0.00006166547,0.0001435267,0.00003195696],"domain_scores_gemma":[0.9995928,0.0001235386,0.0000544796,0.00002101884,0.0001438798,0.00006429301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002368124,0.00008733555,0.0000892763,0.00998755,0.00008565449,0.0001928135,0.00005237283,0.0006848182,0.02448299,0.03093198,0.5476485,0.3855198],"study_design_scores_gemma":[0.00001791826,0.0000527982,0.000097697,0.0002958872,0.00001851256,0.0001605335,0.00000995663,0.0000823064,0.00671624,0.001070984,0.9914623,0.00001482025],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.001237117,0.8915477,0.003496682,0.004722153,0.02197146,0.00008113855,0.0005184977,0.0002984108,0.0761268],"genre_scores_gemma":[0.01212216,0.9066322,0.001892472,0.00320511,0.00561012,0.00008637557,0.0007267759,0.00007903103,0.06964581],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02805324,"threshold_uncertainty_score":0.09384739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009803194382646957,"score_gpt":0.2513385552621076,"score_spread":0.2415353608794606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}