{"id":"W2951889286","doi":"10.1021/ol0489907","title":"Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans","year":2004,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; NS3; Protease inhibitor (pharmacology); Protease; Virology; Combinatorial chemistry; Pharmacology; Biochemistry; Enzyme; Virus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002634088,0.0004811697,0.0003594655,0.0004285302,0.0003005192,0.0002453304,0.0002965862,0.0002606982,0.003335658],"category_scores_gemma":[0.0002247423,0.0002114777,0.0002419925,0.000231328,0.0001742254,0.0002132327,0.0002914309,0.0004350786,0.00214873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000422883,"about_ca_system_score_gemma":0.0007904408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000551175,"about_ca_topic_score_gemma":0.001036266,"domain_scores_codex":[0.999903,0.000019503,0.000008461477,0.00001686861,0.0000275592,0.00002470035],"domain_scores_gemma":[0.9999322,0.000007803778,0.00001086936,0.00000974851,0.00001748047,0.00002192206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004418682,0.0001064297,0.0001731838,0.0003173728,0.0000265019,0.0003740727,0.00006396415,0.001180735,0.9716329,0.0023298,0.0008790842,0.02247404],"study_design_scores_gemma":[0.0001132784,0.001100498,0.0008491479,0.00002786509,0.00004485515,0.0005436321,0.0000166569,0.001334442,0.9719689,0.0004284993,0.02354078,0.00003138228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.825358,0.006951062,0.1059077,0.0007250176,0.0003391335,0.002218013,0.007885409,0.0009750598,0.04964058],"genre_scores_gemma":[0.9124783,0.005066138,0.05992311,0.0002376069,0.00003837719,0.0006061335,0.003921695,0.0001410535,0.0175875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003335658,"threshold_uncertainty_score":0.01115888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002749611153222215,"score_gpt":0.1943780638915993,"score_spread":0.1916284527383771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}