{"id":"W2951889286","doi":"10.1021/ol0489907","title":"Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans","year":2004,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Chemistry; NS3; Protease inhibitor (pharmacology); Protease; Virology; Combinatorial chemistry; Pharmacology; Biochemistry; Enzyme; Virus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444363,0.0001569671,0.0002320717,0.00004974563,0.00002837129,0.00001448357,0.0001600437,0.00008409917,0.0000207985],"category_scores_gemma":[0.00008701452,0.000118084,0.00008289477,0.0001681415,0.00008592393,0.000007682157,0.00004190436,0.00007702385,0.000003997356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003179693,"about_ca_system_score_gemma":0.00003904274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009871663,"about_ca_topic_score_gemma":0.00009648252,"domain_scores_codex":[0.9990879,0.00005880698,0.0001811826,0.0003397592,0.0001272049,0.0002051365],"domain_scores_gemma":[0.9995241,0.00001422566,0.00008057837,0.0003101759,0.00001684531,0.00005403735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008444123,0.0001324575,0.01199616,0.00003847815,0.00004555683,0.00001008069,0.00002728459,0.00001220192,0.986647,0.000002315869,0.00005884669,0.0009451921],"study_design_scores_gemma":[0.0005482735,0.0002230296,0.001608527,0.0000659141,0.00004809621,0.000001227315,0.00001624462,0.000003193574,0.9972247,0.000005350915,0.00008359935,0.000171783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988321,0.00002792184,0.0001366766,0.0007137641,0.0000105519,0.0002057168,0.00000801715,0.00000889434,0.00005637019],"genre_scores_gemma":[0.9992574,0.000006663267,0.0002723077,0.0002686227,0.000107018,0.00003284413,0.00001862085,0.00002705283,0.000009463335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01057777,"threshold_uncertainty_score":0.4815328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002749611153222215,"score_gpt":0.1943780638915993,"score_spread":0.1916284527383771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}