{"id":"W2951913422","doi":"10.1002/chin.200137195","title":"ChemInform Abstract: Design and Synthesis of a Conformationally Restricted trans Peptide Isostere Based on the Bioactive Conformations of Saquinavir and Nelfinavir.","year":2001,"lang":"en","type":"article","venue":"ChemInform","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sciencetech (Canada)","funders":"","keywords":"Chemistry; Nelfinavir; Isostere; Saquinavir; Combinatorial chemistry; Stereochemistry; Human immunodeficiency virus (HIV); Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003347286,0.0006523709,0.0003278255,0.0003122417,0.0002017149,0.0004783405,0.0005231219,0.0004226033,0.00349812],"category_scores_gemma":[0.0002307673,0.0002616454,0.0004521624,0.0002158031,0.000236652,0.0005150373,0.0003096499,0.000843158,0.001863024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003096148,"about_ca_system_score_gemma":0.0004865067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003353507,"about_ca_topic_score_gemma":0.0004925571,"domain_scores_codex":[0.9998821,0.00002153259,0.0000115498,0.0000257508,0.00002722058,0.00003184087],"domain_scores_gemma":[0.9999378,0.000005996851,0.00001387788,0.000005087306,0.00001024187,0.00002702669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008749496,0.0002929929,0.0001884335,0.0004616526,0.00006942877,0.0005771196,0.0001373499,0.0047163,0.9394171,0.004807008,0.002536364,0.04592117],"study_design_scores_gemma":[0.0004989911,0.003288315,0.0004939816,0.0000562884,0.0001263895,0.001129775,0.0000554922,0.003923819,0.9276355,0.0007558705,0.06197412,0.00006145144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.7859331,0.01522839,0.1473219,0.001305314,0.00116847,0.001272566,0.003247749,0.001054631,0.04346767],"genre_scores_gemma":[0.8927734,0.01077577,0.06204659,0.0006636673,0.0001354469,0.0003692718,0.00346453,0.0002062657,0.02956511],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.00349812,"threshold_uncertainty_score":0.01170236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02242413515811718,"score_gpt":0.2422821116366093,"score_spread":0.2198579764784921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}