{"id":"W2951919044","doi":"10.1002/chin.200110158","title":"ChemInform Abstract: New Diarylmethylpiperazines as Potent and Selective Nonpeptidic δ‐Opioid Receptor Agonists with Increased in vitro Metabolic Stability.","year":2001,"lang":"en","type":"article","venue":"ChemInform","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Chemistry; Metabolic stability; In vitro; Opioid receptor; Opioid; Combinatorial chemistry; Pharmacology; Stereochemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001480398,0.0006159927,0.0003197372,0.0002128317,0.000122085,0.0002841547,0.0003711404,0.0003111491,0.006052956],"category_scores_gemma":[0.0001435391,0.0002488056,0.0001740064,0.0002064321,0.0001211384,0.0004822481,0.0002211683,0.0006334836,0.002027308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599164,"about_ca_system_score_gemma":0.000222716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003022017,"about_ca_topic_score_gemma":0.0006837391,"domain_scores_codex":[0.9999484,0.000008847352,0.000004399201,0.000009592579,0.00001621513,0.0000125372],"domain_scores_gemma":[0.9999681,0.000005261102,0.000009556371,0.000002874292,0.000004440105,0.000009883607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002204774,0.0002340609,0.000116982,0.0009891316,0.00006167575,0.0004336868,0.00005577756,0.001228777,0.8737299,0.00187005,0.008778473,0.1102966],"study_design_scores_gemma":[0.001019932,0.004514623,0.001966196,0.00005955893,0.0001205312,0.001166736,0.00001956655,0.001867211,0.9218601,0.0004881357,0.06686378,0.0000536496],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8237895,0.06701732,0.03368113,0.001803987,0.001494363,0.0005469842,0.008525223,0.00213725,0.0610043],"genre_scores_gemma":[0.877914,0.03899479,0.01713373,0.0008770222,0.0002671745,0.0002656927,0.007665075,0.000181824,0.0567006],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.006052956,"threshold_uncertainty_score":0.02024919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01678314747058672,"score_gpt":0.2384310060197405,"score_spread":0.2216478585491538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}