{"id":"W2951938325","doi":"10.1038/s41590-019-0406-1","title":"CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome","year":2019,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Biology; Untranslated region; Gene knockdown; RNA; Three prime untranslated region; Gene; RNA-binding protein; Messenger RNA; Gene expression; Transcription factor; Genetics; Transcription (linguistics); Genome; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001927289,0.0002579762,0.0002538163,0.0001562286,0.00009024466,0.00004383016,0.0004550029,0.0009222898,0.0002984896],"category_scores_gemma":[0.0002974942,0.0002518368,0.0001701799,0.0001751685,0.00007050096,0.00001094036,0.0003385826,0.0008069953,0.0002012418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008935536,"about_ca_system_score_gemma":0.0001944882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002207074,"about_ca_topic_score_gemma":0.00001314708,"domain_scores_codex":[0.9981385,0.0001610843,0.0003168897,0.0006215972,0.0002698988,0.0004920501],"domain_scores_gemma":[0.9986805,0.00002548535,0.0001360002,0.0008530442,0.0001956738,0.0001092576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004369375,0.00005414376,0.001569511,0.00002886304,0.0002010623,0.00001139439,0.00003126627,0.0001648413,0.994866,0.001203936,0.0002793144,0.001152746],"study_design_scores_gemma":[0.003989535,0.0006048103,0.2366344,0.00007539425,0.0001302782,0.00005684609,0.00005426508,0.0007908932,0.7164151,0.001461085,0.03885818,0.0009292074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988905,0.004296539,0.003507961,0.0007784177,0.001138752,0.0005285087,0.00003231723,0.00005680827,0.0007557398],"genre_scores_gemma":[0.9956204,0.0001812342,0.0003734242,0.0005174794,0.0002034993,0.00003249125,0.000346138,0.00005542994,0.0026699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2784508,"threshold_uncertainty_score":0.9999934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003933499761518497,"score_gpt":0.2525347747829457,"score_spread":0.2486012750214272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}