{"id":"W2951938325","doi":"10.1038/s41590-019-0406-1","title":"CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome","year":2019,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Biology; Untranslated region; Gene knockdown; RNA; Three prime untranslated region; Gene; RNA-binding protein; Messenger RNA; Gene expression; Transcription factor; Genetics; Transcription (linguistics); Genome; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00022287,0.0001871188,0.0002157572,0.0003382099,0.0002661168,0.0004994151,0.000241346,0.0003706171,0.003885512],"category_scores_gemma":[0.0005932463,0.00009855472,0.0003021116,0.0003269182,0.0002512555,0.0001884166,0.0002292489,0.0004683484,0.0003146059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003407092,"about_ca_system_score_gemma":0.0002986026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002892517,"about_ca_topic_score_gemma":0.005370005,"domain_scores_codex":[0.9996743,0.00005257122,0.00002610936,0.000124132,0.00005643157,0.00006636378],"domain_scores_gemma":[0.9997732,0.00006917793,0.00006747071,0.00002490284,0.00002046255,0.00004473705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001636984,0.00007265448,0.09322251,0.0001443904,0.0002498185,0.0007872007,0.0002409875,0.000540763,0.8831008,0.001699267,0.0007467776,0.01755788],"study_design_scores_gemma":[0.0000984949,0.0005440917,0.8506613,0.00009734961,0.0005348549,0.003170664,0.0005255634,0.005685783,0.1276563,0.0019778,0.008954342,0.00009337821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950773,0.0009626282,0.001374838,0.0001359651,0.00006830312,0.000009601883,0.001208149,0.00004738976,0.001115821],"genre_scores_gemma":[0.9982791,0.0001107388,0.0003508873,0.0001085328,0.00001161597,0.000008024836,0.0002908274,0.00002370573,0.000816607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003885512,"threshold_uncertainty_score":0.01299834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003933499761518497,"score_gpt":0.2525347747829457,"score_spread":0.2486012750214272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}