{"id":"W2951960637","doi":"10.1101/036293","title":"Phenotypic spandrel: absolute discrimination and ligand antagonism","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Antagonism; Phenotype; Biology; Medicine; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006588563,0.0003678318,0.0005650621,0.0003773651,0.0004716493,0.001441487,0.0008895603,0.001075018,0.003096641],"category_scores_gemma":[0.002441905,0.0001864847,0.0005332154,0.0002264294,0.001849279,0.0019186,0.001715819,0.001588773,0.0004549211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005108691,"about_ca_system_score_gemma":0.0003169837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002487994,"about_ca_topic_score_gemma":0.0001124489,"domain_scores_codex":[0.9994406,0.0001110808,0.00001908049,0.0001623804,0.0001590262,0.0001077886],"domain_scores_gemma":[0.9986956,0.0005137392,0.0002907688,0.0002207732,0.000108155,0.0001710711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001406458,0.0001083214,0.002213887,0.0001484255,0.00002944046,0.001380485,0.0002776812,0.05266803,0.1412602,0.7785033,0.001430436,0.02183923],"study_design_scores_gemma":[0.00003414193,0.0002753358,0.001044154,0.00001825685,0.00001916011,0.001654538,0.0001843071,0.2564363,0.02230681,0.7131606,0.004822608,0.00004370214],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5248955,0.0006162074,0.4253511,0.002758505,0.0001271082,0.00007219205,0.0001243516,0.0004219659,0.04563316],"genre_scores_gemma":[0.9797654,0.0002098066,0.01424403,0.000296462,0.00004004264,0.00003431777,0.00004255595,0.00003995787,0.005327333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003096641,"threshold_uncertainty_score":0.01035929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009436346744950055,"score_gpt":0.2580404541628861,"score_spread":0.2486041074179361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}