{"id":"W2952009489","doi":"10.1016/j.ymthe.2019.04.003","title":"Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"Medical Research Council; Wuhan Union Hospital; NHLBI Division of Intramural Research; Huazhong University of Science and Technology","keywords":"Transduction (biophysics); Rhesus macaque; Haematopoiesis; Biology; Viral vector; Virology; Macaque; Vector (molecular biology); Progenitor cell; Cell biology; Genetics; Stem cell; Gene; Recombinant DNA; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002841759,0.0002056179,0.0002727713,0.0001280553,0.00002706855,0.0000152583,0.0002602683,0.0001709332,0.0001517711],"category_scores_gemma":[0.00001054594,0.0002057487,0.0003057119,0.0002269429,0.00005058487,0.000006983167,0.00002368409,0.0001451527,0.00002194498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002317996,"about_ca_system_score_gemma":0.000102319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005862388,"about_ca_topic_score_gemma":0.00008467514,"domain_scores_codex":[0.9984386,0.0001920781,0.0002859932,0.0004127505,0.0003218215,0.0003487741],"domain_scores_gemma":[0.9993578,0.00001079298,0.00006748375,0.0004626792,0.00004692396,0.00005432037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002067411,0.0001290545,0.003188881,0.00002261548,0.0001655128,0.00001842866,0.0001123164,0.0002415303,0.9890198,0.00003719458,0.00001454028,0.004982748],"study_design_scores_gemma":[0.002445814,0.00151255,0.002739465,0.00002699965,0.000006402212,0.000007305972,0.00004795569,0.00008563478,0.9920409,0.0001387254,0.0007270317,0.00022116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957774,0.002543619,0.0004920349,0.0001779938,0.0001635448,0.0004783038,0.00001029946,0.00001132345,0.0003454303],"genre_scores_gemma":[0.9989688,0.0003083722,0.0002185959,0.0001673094,0.00004375366,0.0000293899,0.00006300002,0.0000430042,0.0001577376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004761587,"threshold_uncertainty_score":0.8390189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227254115201023,"score_gpt":0.276383529977044,"score_spread":0.2641109888250338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}