{"id":"W2952009489","doi":"10.1016/j.ymthe.2019.04.003","title":"Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"Medical Research Council; Wuhan Union Hospital; NHLBI Division of Intramural Research; Huazhong University of Science and Technology","keywords":"Transduction (biophysics); Rhesus macaque; Haematopoiesis; Biology; Viral vector; Virology; Macaque; Vector (molecular biology); Progenitor cell; Cell biology; Genetics; Stem cell; Gene; Recombinant DNA; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472441,0.0001277943,0.000180507,0.0002807105,0.0002244761,0.0002628619,0.0001517079,0.0003176229,0.0007214806],"category_scores_gemma":[0.0002197379,0.00009350591,0.0001182855,0.0001133952,0.0002587546,0.000136554,0.0001745094,0.0005278938,0.0001554443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000231111,"about_ca_system_score_gemma":0.0002192336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002362103,"about_ca_topic_score_gemma":0.002359699,"domain_scores_codex":[0.9998862,0.0000192966,0.000008648469,0.00002338621,0.00002820878,0.00003421485],"domain_scores_gemma":[0.9998271,0.00006060961,0.00003222374,0.00003298639,0.00001775356,0.00002943854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001319953,0.00003777469,0.000632915,0.00001310005,0.000005091326,0.0004822714,0.00007425516,0.00006754938,0.9959294,0.0003719889,0.00003971686,0.002213927],"study_design_scores_gemma":[0.00002103707,0.0006685737,0.01374866,0.000008285409,0.00003865047,0.003029233,0.0001246362,0.002329827,0.9769878,0.0002427499,0.002793322,0.000007167655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980494,0.0002686757,0.0008213191,0.00003432843,0.000009133837,0.00001709444,0.00007081522,0.00003095943,0.000698255],"genre_scores_gemma":[0.9973266,0.0001709991,0.0005683592,0.00002362906,0.000005203268,0.00001701699,0.00008783296,0.00001606072,0.001784314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002362103,"threshold_uncertainty_score":0.004696786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227254115201023,"score_gpt":0.276383529977044,"score_spread":0.2641109888250338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}