{"id":"W2952011218","doi":"10.1016/j.jmb.2018.04.028","title":"S -Nitrosylation of STIM1 by Neuronal Nitric Oxide Synthase Inhibits Store-Operated Ca 2+ Entry","year":2018,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institutes of Health; Canadian Institutes of Health Research; Nantong University; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"STIM1; Endoplasmic reticulum; ORAI1; Cell biology; Chemistry; Nitric oxide; Nitric oxide synthase; S-Nitrosylation; Nitrosylation; HEK 293 cells; Biophysics; Biochemistry; Biology; Cysteine; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002808949,0.0001290599,0.000248302,0.0002014847,0.00007042555,0.0000118253,0.0002087051,0.0001357502,0.0001503894],"category_scores_gemma":[0.0007538358,0.0000971322,0.0001110522,0.0002966859,0.0002556001,0.0000748595,0.00005017343,0.0002330755,0.00002062623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002955524,"about_ca_system_score_gemma":0.00009356901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001074674,"about_ca_topic_score_gemma":4.33475e-7,"domain_scores_codex":[0.9985228,0.0004139895,0.0004639917,0.0001827234,0.0001994643,0.0002170075],"domain_scores_gemma":[0.999013,0.00011418,0.000437562,0.00008859231,0.0002413056,0.0001053579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001659227,0.000103373,0.0002010708,0.000004896762,0.0000112384,0.00002080647,0.00002252375,0.00006029472,0.997224,0.0001238599,0.001558987,0.0005030353],"study_design_scores_gemma":[0.0005964986,0.0007028964,0.0002213249,0.00001891149,0.00001712178,0.0001459877,0.00001276314,0.000278927,0.9958385,0.0001855428,0.001887039,0.00009447196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945897,0.0002305481,0.004061079,0.0002275468,0.0005868478,0.00007663367,0.00002895866,0.000007199766,0.0001915228],"genre_scores_gemma":[0.9989341,0.00008123137,0.0002119829,0.0004995542,0.0001682393,8.174944e-7,0.000004966568,0.0000140269,0.00008502695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004344491,"threshold_uncertainty_score":0.3960936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286012327679399,"score_gpt":0.2752202210218145,"score_spread":0.2623600977450206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}