{"id":"W2952011218","doi":"10.1016/j.jmb.2018.04.028","title":"S -Nitrosylation of STIM1 by Neuronal Nitric Oxide Synthase Inhibits Store-Operated Ca 2+ Entry","year":2018,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institutes of Health; Canadian Institutes of Health Research; Nantong University; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"STIM1; Endoplasmic reticulum; ORAI1; Cell biology; Chemistry; Nitric oxide; Nitric oxide synthase; S-Nitrosylation; Nitrosylation; HEK 293 cells; Biophysics; Biochemistry; Biology; Cysteine; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002863423,0.0003098445,0.0004158621,0.000131214,0.0002389136,0.000214011,0.0002941845,0.0002926448,0.001892721],"category_scores_gemma":[0.000310096,0.0001355637,0.0003248422,0.0001367785,0.0004054387,0.0002857854,0.0002408897,0.0006333149,0.0002994119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003376628,"about_ca_system_score_gemma":0.0005115845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008764922,"about_ca_topic_score_gemma":0.002035073,"domain_scores_codex":[0.9998761,0.00002082833,0.00001289017,0.00001334378,0.00001864621,0.00005817304],"domain_scores_gemma":[0.9998699,0.00003756491,0.00002588336,0.00002085926,0.00001098248,0.00003478058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001594409,0.0001600085,0.000200601,0.00007353632,0.00002179665,0.00007865286,0.00005448722,0.0001342957,0.9948954,0.0003334896,0.0002460171,0.002207291],"study_design_scores_gemma":[0.0001272488,0.001116875,0.003792657,0.00001003095,0.00002483845,0.0002218883,0.00005888973,0.001655424,0.9914022,0.0001339852,0.001447397,0.000008529462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973741,0.0007772669,0.0005138523,0.000140689,0.00006797419,0.0000159965,0.0001021085,0.00003833765,0.0009696411],"genre_scores_gemma":[0.9970171,0.0006777824,0.000590283,0.00006061394,0.00002762329,0.00002643072,0.0003302326,0.00001207453,0.001257833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892721,"threshold_uncertainty_score":0.006331742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286012327679399,"score_gpt":0.2752202210218145,"score_spread":0.2623600977450206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}