{"id":"W2952012622","doi":"10.1002/chin.200416178","title":"cycloSaligenyl Pronucleotides of 5‐Iodo and 5‐Trifluoromethyl‐1‐ (2‐deoxy‐β‐D‐ribofuranosyl)‐2,4‐difluorobenzene Mimics of Thymidine: Synthesis and Evaluation of This Pronucleotide Monophosphate Delivery System for Compounds with Potential Anticancer Activity.","year":2004,"lang":"en","type":"article","venue":"ChemInform","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Trifluoromethyl; Thymidine; Stereochemistry; Combinatorial chemistry; Medicinal chemistry; Organic chemistry; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002054539,0.0004443107,0.0001362605,0.0001125897,0.0001253673,0.0001839215,0.0002347919,0.0003446509,0.002394399],"category_scores_gemma":[0.000273669,0.0001403624,0.0001222586,0.0001020459,0.0001576791,0.0002554934,0.0001915248,0.0004462754,0.0006098046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002841236,"about_ca_system_score_gemma":0.0003782614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008719583,"about_ca_topic_score_gemma":0.001768822,"domain_scores_codex":[0.9998735,0.00002776601,0.000007856148,0.00003225838,0.0000245435,0.00003397255],"domain_scores_gemma":[0.9998761,0.0000388046,0.00003091462,0.00001086658,0.00001499345,0.00002826607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00024957,0.00001752409,0.00006095817,0.00007473162,0.000004688573,0.0000769678,0.00002465245,0.0001825629,0.9951345,0.0004696179,0.00006459944,0.003639573],"study_design_scores_gemma":[0.00001798452,0.000384356,0.0002423709,0.000006284218,0.000005671473,0.0001388369,0.000008831458,0.0003175831,0.9946162,0.00004661965,0.004210244,0.000004920699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956149,0.003459202,0.0256795,0.0001943784,0.0001765389,0.0002646573,0.0006459113,0.0002120631,0.0132188],"genre_scores_gemma":[0.9750044,0.00149034,0.01315321,0.00009204658,0.00001867705,0.0001187601,0.0006105294,0.00003064708,0.009481294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002394399,"threshold_uncertainty_score":0.008010089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008680171762821907,"score_gpt":0.2267448061985166,"score_spread":0.2180646344356947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}