{"id":"W2952014119","doi":"10.1038/s41467-018-08126-5","title":"C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"RIKEN; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Enhancer; Cage; Transcription (linguistics); Transcription factor; Enhancer RNAs; Computational biology; Biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002362773,0.0001640522,0.0001957654,0.0001069671,0.0005026448,0.00002199114,0.0004053968,0.0005455191,0.0003385415],"category_scores_gemma":[0.00004970747,0.000156105,0.00007856102,0.0001530804,0.0002323125,0.0001962111,0.0001669772,0.0008833052,0.0003928223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001155368,"about_ca_system_score_gemma":0.00003445378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006416606,"about_ca_topic_score_gemma":0.0005278239,"domain_scores_codex":[0.9987901,0.000529447,0.0001732572,0.000227893,0.00003798947,0.0002412573],"domain_scores_gemma":[0.9982249,0.000394138,0.0001094627,0.001182069,0.00007505695,0.00001442621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004324999,0.0001905758,0.0005844941,0.00001289135,0.00005077063,1.405394e-7,0.0008528769,9.47584e-7,0.9939687,0.0001439329,0.001031336,0.002730781],"study_design_scores_gemma":[0.001077903,0.0002075416,0.01225467,0.00002962706,0.00003398642,0.00001994412,0.000136992,0.0000182234,0.7397223,0.00002638781,0.2462772,0.0001951839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9086965,0.08727758,0.00003489487,0.0009760328,0.0002890858,0.0003350741,0.00004263326,0.00008570135,0.002262546],"genre_scores_gemma":[0.9872891,0.002634807,0.0002414718,0.000187215,0.00000815314,0.00002744364,0.0001828554,0.00001945494,0.009409515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2542464,"threshold_uncertainty_score":0.6365778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01973670682254959,"score_gpt":0.2563731074557946,"score_spread":0.236636400633245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}