{"id":"W2952014600","doi":"10.1016/j.ejpb.2019.06.013","title":"Dual delivery of nucleic acids and PEGylated-bisphosphonates via calcium phosphate nanoparticles","year":2019,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Staatssekretariat für Bildung, Forschung und Innovation; Natural Sciences and Engineering Research Council of Canada; Singapore Eye Research Institute","keywords":"Transfection; Gene delivery; Chemistry; In vivo; Internalization; Drug delivery; Conjugate; Biophysics; Calcium; Nucleic acid; Biochemistry; Cell; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006822641,0.0002529869,0.0003031319,0.00009585423,0.00006585623,0.00004772122,0.0002279346,0.00006647232,0.00005405501],"category_scores_gemma":[0.00001714455,0.0002179111,0.0001232865,0.0001125059,0.0001748138,0.0000257125,0.0002562984,0.000262629,0.00001670005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009548675,"about_ca_system_score_gemma":0.00005247243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002814462,"about_ca_topic_score_gemma":4.610451e-7,"domain_scores_codex":[0.9984221,0.0001736804,0.0006252629,0.000253526,0.0002258982,0.0002995451],"domain_scores_gemma":[0.9988207,0.00002665111,0.0004135029,0.0001721167,0.0003132127,0.0002538752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005749881,0.00009290993,0.01136259,0.00008349619,0.0002321382,0.0000747909,0.0001810246,0.00006645646,0.9697166,0.00001365787,0.0001997789,0.01740156],"study_design_scores_gemma":[0.00222223,0.0009234404,0.0037745,0.00006510344,0.0001826263,0.0003367643,0.0002054679,0.001215011,0.9624947,0.00001491179,0.0282971,0.0002681635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837107,0.0151764,0.00009281581,0.0001259009,0.0005099513,0.0001235813,0.00002571521,0.000006475133,0.0002284634],"genre_scores_gemma":[0.9861876,0.01246028,0.0004638115,0.0004891955,0.0001617723,3.586892e-7,0.000006702342,0.00003989436,0.0001903651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02809733,"threshold_uncertainty_score":0.8886157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02096658013910725,"score_gpt":0.2742539664885308,"score_spread":0.2532873863494236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}