{"id":"W2952033512","doi":"10.1016/j.devcel.2019.05.026","title":"Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane","year":2019,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Carlsbergfondet; St Peter’s Trust for Kidney Bladder and Prostate Research","keywords":"Internalization; Scavenger receptor; Biology; Endocytic cycle; Cell biology; Receptor; Endocytosis; Transferrin receptor; Biophysics; LDL receptor; Cell membrane; Cytoskeleton; Membrane; Biochemistry; Lipoprotein; Cholesterol; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001744838,0.00006246661,0.00005650591,0.00001583049,0.00003321777,0.000008747221,0.00009751746,0.00005693531,0.00009637333],"category_scores_gemma":[0.000008170804,0.00003953754,0.00002527118,0.00006810862,0.00001870137,0.000003211823,0.00004826149,0.00004307518,0.000008963974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007041529,"about_ca_system_score_gemma":0.00002037789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006716276,"about_ca_topic_score_gemma":0.000005072925,"domain_scores_codex":[0.999527,0.00004959247,0.0001210409,0.0001302032,0.00009383183,0.00007831227],"domain_scores_gemma":[0.9998311,0.000006872351,0.00005297163,0.00008354698,0.00001463593,0.00001082543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001764401,0.00001649731,0.003967573,0.00001690604,0.000004054812,7.263596e-8,0.0002497842,0.00001183976,0.994841,0.00001826484,0.00005583131,0.0008005353],"study_design_scores_gemma":[0.0003306337,0.00003380768,0.004472199,0.00001493001,0.000002487949,0.000002370114,0.0004478335,0.00008537297,0.990835,0.000006664121,0.003705963,0.00006274034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998126,0.00006632563,0.00004287901,0.00003171402,0.0001358313,0.000198711,0.000003324413,0.000001490875,0.001393714],"genre_scores_gemma":[0.9979904,0.00007195094,0.001128711,0.00006286948,0.00001535559,0.000006264822,0.00005017694,0.000006647931,0.0006676103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004005999,"threshold_uncertainty_score":0.1612294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006568787612370914,"score_gpt":0.1855236286836245,"score_spread":0.1789548410712535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}