{"id":"W2952033512","doi":"10.1016/j.devcel.2019.05.026","title":"Multimerization and Retention of the Scavenger Receptor SR-B1 in the Plasma Membrane","year":2019,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Carlsbergfondet; St Peter’s Trust for Kidney Bladder and Prostate Research","keywords":"Internalization; Scavenger receptor; Biology; Endocytic cycle; Cell biology; Receptor; Endocytosis; Transferrin receptor; Biophysics; LDL receptor; Cell membrane; Cytoskeleton; Membrane; Biochemistry; Lipoprotein; Cholesterol; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002842116,0.0001454175,0.0001733088,0.0003215766,0.0003379612,0.0004159767,0.0002760644,0.0004410243,0.001425401],"category_scores_gemma":[0.0002562997,0.0002080796,0.000298152,0.0001774823,0.0002174368,0.0005203803,0.0003454203,0.0008086517,0.0007639115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000760705,"about_ca_system_score_gemma":0.0003156809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008724087,"about_ca_topic_score_gemma":0.0009582617,"domain_scores_codex":[0.9998119,0.00002926008,0.00001579381,0.00004343736,0.00004690951,0.00005252949],"domain_scores_gemma":[0.9998196,0.0000303263,0.00004200961,0.00004428631,0.00002792442,0.00003600348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005201511,0.00000525386,0.0001008811,0.00001078692,0.000002519145,0.00004329631,0.00001605285,0.00002165112,0.9986298,0.0004118023,0.00004196734,0.0006640308],"study_design_scores_gemma":[0.00001339072,0.00005174687,0.006928671,0.000005835329,0.000009939188,0.0006118021,0.00006957805,0.0008400791,0.9878471,0.0002549678,0.003360001,0.00000691803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908763,0.003295652,0.00344691,0.0004272108,0.00004956925,0.00000817016,0.0002150812,0.00005849381,0.001622554],"genre_scores_gemma":[0.9898135,0.001057337,0.002222617,0.00009120048,0.00002482823,0.00001489702,0.0005416836,0.00002744699,0.006206491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001425401,"threshold_uncertainty_score":0.005519331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006568787612370914,"score_gpt":0.1855236286836245,"score_spread":0.1789548410712535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}