{"id":"W2952058359","doi":"10.1101/681296","title":"Sperm DNA damage causes genomic instability in early embryonic development","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Genome instability; Biology; Sperm; DNA damage; Embryo; Chromothripsis; Genetics; Zygote; Blastomere; Genome; Embryonic stem cell; DNA fragmentation; Embryogenesis; DNA; Gene; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964602,0.0002157346,0.0002424574,0.0004597797,0.0002010435,0.0002690722,0.0001178222,0.0003731521,0.005241469],"category_scores_gemma":[0.0002819134,0.0001512329,0.000144624,0.0002370858,0.0001637254,0.0001193318,0.0002107596,0.0003276318,0.001433338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000191276,"about_ca_system_score_gemma":0.0001235552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003467283,"about_ca_topic_score_gemma":0.0003477775,"domain_scores_codex":[0.9998506,0.00002040398,0.000009868319,0.00002694142,0.00007968995,0.00001240116],"domain_scores_gemma":[0.9998338,0.00005174825,0.0000412514,0.00001710417,0.00003513309,0.00002088132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001200185,0.00001195229,0.002425717,0.0001298532,0.00001755141,0.0008204372,0.00005183562,0.0001947639,0.9881665,0.0003512617,0.001577136,0.006132961],"study_design_scores_gemma":[0.00002071266,0.0002352079,0.05890986,0.00003279744,0.00004988014,0.004774057,0.00008183756,0.001733031,0.9110732,0.0008266155,0.02224671,0.0000160794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633738,0.006577847,0.01321733,0.001078402,0.0005687174,0.00004185888,0.002663601,0.0006360034,0.01184243],"genre_scores_gemma":[0.9693978,0.002603434,0.004149276,0.0002052127,0.0001463588,0.00002084452,0.002178974,0.000192234,0.02110585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005241469,"threshold_uncertainty_score":0.01753449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02231257545684635,"score_gpt":0.2417034778016999,"score_spread":0.2193909023448536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}