{"id":"W2952071797","doi":"10.1101/257527","title":"Crystal structure of chromo barrel domain of RBBP1","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Ontario Ministry of Research, Innovation and Science; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Biological and Environmental Research; National Natural Science Foundation of China; University of Chicago; Pfizer; Novartis Pharma; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Argonne National Laboratory; U.S. Department of Energy","keywords":"Histone; Chemistry; Biophysics; HMG-box; Binding domain; DNA-binding domain; DNA; Cell biology; Biochemistry; Binding site; Biology; Transcription factor; DNA-binding protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001722295,0.0004270955,0.0004409466,0.000248721,0.0005319737,0.0005122154,0.0005571391,0.0003850723,0.002121052],"category_scores_gemma":[0.0002956026,0.0002209008,0.0001900669,0.0004175931,0.0001806572,0.0002034852,0.0002721756,0.0009430212,0.0005506602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009864001,"about_ca_system_score_gemma":0.0006844468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005405254,"about_ca_topic_score_gemma":0.003939647,"domain_scores_codex":[0.9998933,0.00001173685,0.00000429245,0.00002746938,0.00004026217,0.00002293134],"domain_scores_gemma":[0.9998988,0.00001757395,0.00001691573,0.000003800567,0.00002996662,0.00003297938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002494001,0.0006877895,0.0121501,0.001046279,0.0002206682,0.00223729,0.0007174566,0.01177372,0.9280707,0.004472824,0.01551925,0.02060981],"study_design_scores_gemma":[0.001175522,0.0006447899,0.06819539,0.0001966674,0.0004171582,0.002393647,0.001474073,0.1400565,0.6952975,0.003233634,0.08670782,0.0002072914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769568,0.005119289,0.006137371,0.0007966003,0.0002066265,0.00006401876,0.004775099,0.0004827888,0.00546139],"genre_scores_gemma":[0.9720414,0.001735542,0.006340938,0.0002315619,0.00003105764,0.00005133569,0.01413573,0.00009139576,0.005341141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005405254,"threshold_uncertainty_score":0.01074755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008565170820915787,"score_gpt":0.2187704501396368,"score_spread":0.210205279318721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}