{"id":"W2952073529","doi":"10.1371/journal.ppat.1007723","title":"Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Institute of Infection and Immunity; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; U.S. Public Health Service; Office of Science; Argonne National Laboratory; U.S. Department of Energy","keywords":"Teichoic acid; Bacteria; Glycosyltransferase; Mechanism (biology); Pathogenic bacteria; Microbiology; Chemistry; Biochemistry; Cell wall; Biology; Peptidoglycan; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001869618,0.0002550201,0.0003593289,0.00006793656,0.00003952299,0.00001188644,0.0001768879,0.0002495159,0.00003192555],"category_scores_gemma":[0.00006865356,0.0002352752,0.0000900985,0.0001144069,0.00004717567,0.000002159397,0.0001094122,0.000117579,0.000002129147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001668065,"about_ca_system_score_gemma":0.000064022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001947706,"about_ca_topic_score_gemma":0.000190685,"domain_scores_codex":[0.9986539,0.00007832324,0.0002766753,0.0005279046,0.0001481694,0.0003150052],"domain_scores_gemma":[0.9993573,0.00002576334,0.0001086203,0.0003594825,0.00008000041,0.00006886263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007488542,0.0001198824,0.06395767,0.00006932996,0.0001416825,0.000002538242,0.000308153,0.00001184697,0.935181,0.00005848041,0.000002231663,0.00007225751],"study_design_scores_gemma":[0.001277787,0.0003212395,0.1085506,0.00003615562,0.00006488449,0.000008593522,0.00009345307,0.00006748777,0.8889989,0.0001842844,0.0001068369,0.0002898198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979383,0.0005723436,0.00001175981,0.00005353284,0.0001564769,0.0005082898,0.0006888503,0.000005035236,0.00006546143],"genre_scores_gemma":[0.9984185,0.0004814339,0.000666699,0.00009510408,0.0000431958,0.00002132825,0.0001184441,0.00003665849,0.0001186136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04618218,"threshold_uncertainty_score":0.9594243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042896819848897,"score_gpt":0.1978162379002016,"score_spread":0.1873872697017126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}