{"id":"W2952073529","doi":"10.1371/journal.ppat.1007723","title":"Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria","year":2019,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Institute of Infection and Immunity; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; U.S. Public Health Service; Office of Science; Argonne National Laboratory; U.S. Department of Energy","keywords":"Teichoic acid; Bacteria; Glycosyltransferase; Mechanism (biology); Pathogenic bacteria; Microbiology; Chemistry; Biochemistry; Cell wall; Biology; Peptidoglycan; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001085174,0.0002863322,0.0001814032,0.0001290252,0.0001745343,0.0003733118,0.0003929012,0.0004663762,0.0003828235],"category_scores_gemma":[0.0001012616,0.0001668996,0.0002270131,0.0001167698,0.0003876437,0.0003381577,0.0001679433,0.0004106132,0.0003925508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005515135,"about_ca_system_score_gemma":0.0003880688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001761866,"about_ca_topic_score_gemma":0.0006964374,"domain_scores_codex":[0.9999573,0.00000576416,0.000002620991,0.00001573594,0.000009970086,0.000008547929],"domain_scores_gemma":[0.9999427,0.000006173497,0.00001935444,0.000005695173,0.000007888541,0.00001833913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002144717,0.00007814436,0.001900053,0.0001166205,0.00001088513,0.0003977887,0.00006359014,0.002326859,0.9863662,0.00335024,0.0001836408,0.004991533],"study_design_scores_gemma":[0.00006689463,0.0005689778,0.02132972,0.00002418857,0.00002867006,0.00143946,0.000142501,0.03466719,0.9297629,0.00212963,0.009800581,0.00003922495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984608,0.004444839,0.007579057,0.0004293468,0.00004266429,0.00004153071,0.0003467062,0.0001028356,0.002405164],"genre_scores_gemma":[0.9930978,0.001307558,0.003018965,0.00006431861,0.00001518502,0.00001615236,0.0004756383,0.00001206723,0.001992336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001761866,"threshold_uncertainty_score":0.004001498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042896819848897,"score_gpt":0.1978162379002016,"score_spread":0.1873872697017126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}