{"id":"W2952079965","doi":"10.1002/chin.201005279","title":"ChemInform Abstract: Ultrahigh‐Throughput FACS‐Based Screening for Directed Enzyme Evolution","year":2010,"lang":"en","type":"article","venue":"ChemInform","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Throughput; High-throughput screening; Enzyme; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007796205,0.0009156836,0.0004528014,0.0007634756,0.0004339038,0.0008322579,0.000724658,0.0006003215,0.01318033],"category_scores_gemma":[0.0005369375,0.0003977125,0.000277152,0.0005511101,0.0002322464,0.0004261571,0.0004445215,0.001019333,0.007748634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006301134,"about_ca_system_score_gemma":0.0006382652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008816503,"about_ca_topic_score_gemma":0.001607285,"domain_scores_codex":[0.9994481,0.00007617145,0.00003370232,0.00007037012,0.0003117563,0.00005986011],"domain_scores_gemma":[0.9997558,0.00007040126,0.00001894244,0.00003211676,0.00007788971,0.0000447463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003758154,0.0001340024,0.000408094,0.0001384114,0.00001658738,0.00003875926,0.00001863992,0.0004738603,0.9733426,0.0006504331,0.007882763,0.01652011],"study_design_scores_gemma":[0.00003912289,0.0001436851,0.0008183228,0.000009960245,0.00001702062,0.0001020327,0.000009531944,0.002922769,0.9834659,0.0001741218,0.01228357,0.00001394372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5242575,0.005681561,0.3048123,0.003134158,0.001288268,0.002007094,0.05649949,0.01753436,0.08478531],"genre_scores_gemma":[0.6638733,0.004788741,0.1831018,0.0009703528,0.0001735556,0.0009206341,0.06622453,0.001462234,0.07848486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01318033,"threshold_uncertainty_score":0.04409266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211368145705071,"score_gpt":0.2503004801793232,"score_spread":0.2381867987222725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}