{"id":"W2952089805","doi":"10.1111/bjd.18220","title":"<scp>AURIEL</scp> ‐PsO: a randomized, double‐blind phase <scp>III</scp> equivalence trial to demonstrate the clinical similarity of the proposed biosimilar <scp>MSB</scp> 11022 to reference adalimumab in patients with moderate‐to‐severe chronic plaque‐type psoriasis","year":2019,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Fresenius Kabi; Merck","keywords":"Biosimilar; Equivalence (formal languages); Medicine; Double blind; Similarity (geometry); Adalimumab; Mathematics; Computer science; Internal medicine; Artificial intelligence; Discrete mathematics; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003347036,0.0006424203,0.002808069,0.0003741717,0.000350797,0.0001423011,0.001860835,0.001176754,0.00006221641],"category_scores_gemma":[0.005390784,0.0004283837,0.0006344426,0.001174231,0.001050786,0.0002821783,0.0005768954,0.002468423,0.00005789552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001449189,"about_ca_system_score_gemma":0.001245429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001063856,"about_ca_topic_score_gemma":0.0003441524,"domain_scores_codex":[0.9903391,0.003974963,0.002982818,0.0009163643,0.0004721197,0.001314652],"domain_scores_gemma":[0.9908943,0.005255843,0.001553929,0.0008419132,0.001097511,0.0003564671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8164873,0.0113051,0.03808125,0.0005585967,0.006400279,0.001124957,0.003245141,0.0007194097,0.01390181,0.001291111,0.08654119,0.02034383],"study_design_scores_gemma":[0.9109792,0.007395958,0.007944192,0.00126067,0.001101259,0.003894201,0.0009032013,0.00009819673,0.05236165,0.0006154227,0.01316539,0.0002807263],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887635,0.001989328,0.0005187858,0.001665949,0.002113359,0.004294319,0.0001822203,0.00002878109,0.0004438213],"genre_scores_gemma":[0.9954644,0.0005729523,0.001189937,0.002124912,0.0001439528,0.00005859232,0.00002078761,0.00005657623,0.0003678414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09449181,"threshold_uncertainty_score":0.9998329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03661824537907298,"score_gpt":0.3225131638699592,"score_spread":0.2858949184908862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}