{"id":"W2952089805","doi":"10.1111/bjd.18220","title":"<scp>AURIEL</scp> ‐PsO: a randomized, double‐blind phase <scp>III</scp> equivalence trial to demonstrate the clinical similarity of the proposed biosimilar <scp>MSB</scp> 11022 to reference adalimumab in patients with moderate‐to‐severe chronic plaque‐type psoriasis","year":2019,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Fresenius Kabi; Merck","keywords":"Biosimilar; Equivalence (formal languages); Medicine; Double blind; Similarity (geometry); Adalimumab; Mathematics; Computer science; Internal medicine; Artificial intelligence; Discrete mathematics; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002652851,0.001652367,0.002073656,0.0004610498,0.0005494913,0.0009357295,0.0008861379,0.001870326,0.008050255],"category_scores_gemma":[0.001955376,0.0007064332,0.001393447,0.0003085598,0.001548555,0.0009346909,0.0005623432,0.002969379,0.001108436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007619137,"about_ca_system_score_gemma":0.001652055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007439226,"about_ca_topic_score_gemma":0.00135546,"domain_scores_codex":[0.9988225,0.000678201,0.00007152203,0.0001753981,0.0001182679,0.0001340832],"domain_scores_gemma":[0.9987116,0.0002859061,0.000304601,0.0001311048,0.0001028394,0.0004640076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9697812,0.01694274,0.0003129778,0.0002546708,0.000265893,0.00002237311,0.0000378281,0.0001523214,0.003632979,0.000106715,0.0005126353,0.007977726],"study_design_scores_gemma":[0.9326354,0.06583126,0.0005342216,0.000009309534,0.0001027623,0.00001852068,0.000005552714,0.0002186725,0.0003716169,0.00004991589,0.0002172161,0.000005425571],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880794,0.0009064742,0.0008450107,0.0004093836,0.0002993797,0.007069705,0.0005727774,0.0001149684,0.001702888],"genre_scores_gemma":[0.9867308,0.0006404007,0.001933767,0.0008649488,0.00035577,0.006427105,0.0008049356,0.00002521696,0.002217053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008050255,"threshold_uncertainty_score":0.02693081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03661824537907298,"score_gpt":0.3225131638699592,"score_spread":0.2858949184908862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}