{"id":"W2952101186","doi":"10.1055/s-2007-983811","title":"Unprecedented One-Pot Stereoselective Synthesis of Knoevenagel-Type Derivatives via in situ Condensation of <i>N</i>-Methyleniminium Salts of Ethylenethiourea and Ethyleneurea with Active Methylene Reagents","year":2007,"lang":"en","type":"article","venue":"Synthesis","topic":"Advanced Synthetic Organic Chemistry","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Illinois at Chicago; Ryerson University; Compagnia di San Paolo","keywords":"Chemistry; Stereoselectivity; Knoevenagel condensation; Methylene; Reagent; Triethylamine; Organic chemistry; Cyanohydrin; Dimethylformamide; Medicinal chemistry; Condensation reaction; Chloride; Benzoic acid; Catalysis; Solvent","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262613,0.0005429457,0.0002481123,0.0001553124,0.0001395209,0.0002195484,0.0005212551,0.0002545284,0.001050838],"category_scores_gemma":[0.0001514866,0.0002252262,0.0002248482,0.0002169669,0.0001557045,0.0002591988,0.0003405454,0.0003640696,0.0005993588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002687072,"about_ca_system_score_gemma":0.0002839413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005019261,"about_ca_topic_score_gemma":0.001523592,"domain_scores_codex":[0.9999033,0.00001153287,0.00001052462,0.00002680833,0.00001635948,0.00003145879],"domain_scores_gemma":[0.9999348,0.000007100406,0.00001840088,0.000009137923,0.00001052235,0.00002014567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005635452,0.0000222341,0.0001094483,0.0001051445,0.000009773812,0.0001575815,0.00004648023,0.0001575878,0.9960509,0.0003762614,0.00008860774,0.00281974],"study_design_scores_gemma":[0.000009794805,0.0001456547,0.0003420588,0.000003674187,0.000007710182,0.0001139194,0.00000895666,0.0001951888,0.9954125,0.00002807732,0.003726327,0.000006080062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673534,0.002161165,0.01527073,0.00009045877,0.00009574464,0.0001382904,0.001043076,0.0003099891,0.01353708],"genre_scores_gemma":[0.9796825,0.00155274,0.01295546,0.00005118832,0.00001129836,0.00005805826,0.0007000813,0.00007106253,0.004917509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050838,"threshold_uncertainty_score":0.003515363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362537098154026,"score_gpt":0.2540201575574481,"score_spread":0.2403947865759078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}