{"id":"W2952101186","doi":"10.1055/s-2007-983811","title":"Unprecedented One-Pot Stereoselective Synthesis of Knoevenagel-Type Derivatives via in situ Condensation of <i>N</i>-Methyleniminium Salts of Ethylenethiourea and Ethyleneurea with Active Methylene Reagents","year":2007,"lang":"en","type":"article","venue":"Synthesis","topic":"Advanced Synthetic Organic Chemistry","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Illinois at Chicago; Ryerson University; Compagnia di San Paolo","keywords":"Chemistry; Stereoselectivity; Knoevenagel condensation; Methylene; Reagent; Triethylamine; Organic chemistry; Cyanohydrin; Dimethylformamide; Medicinal chemistry; Condensation reaction; Chloride; Benzoic acid; Catalysis; Solvent","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009068532,0.0005185255,0.001271033,0.0003301582,0.00005781068,0.000007663255,0.0004072267,0.0005017633,0.0002071188],"category_scores_gemma":[0.00258875,0.000505751,0.0001309139,0.0008034823,0.0006474631,0.0002075318,0.0001517666,0.0004691707,0.000001532466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002000075,"about_ca_system_score_gemma":0.000173873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000207684,"about_ca_topic_score_gemma":0.000317271,"domain_scores_codex":[0.996555,0.0002124663,0.001227037,0.000754349,0.0007256191,0.0005255863],"domain_scores_gemma":[0.9916207,0.005558031,0.001388373,0.0007446881,0.0005256066,0.0001626429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002214634,0.0005044244,0.004437447,0.0009563538,0.000514895,0.00000992335,0.003034597,0.00001839529,0.9611385,0.00001951493,0.000001816196,0.02714943],"study_design_scores_gemma":[0.0007879241,0.0001215811,0.01854272,0.001119291,0.0003161881,0.00001741519,0.003783853,0.00001464495,0.9745588,0.0003073,0.000009611663,0.000420678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930366,0.0002647868,0.001556826,0.00006936947,0.00003349477,0.0002650601,0.00009159745,0.00004743512,0.004634853],"genre_scores_gemma":[0.991932,0.0002557434,0.007549827,0.00001207726,0.00003127469,0.00003134604,0.00001090759,0.000098271,0.00007859818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02672875,"threshold_uncertainty_score":0.9997394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362537098154026,"score_gpt":0.2540201575574481,"score_spread":0.2403947865759078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}