{"id":"W2952105231","doi":"10.1038/s41467-019-10523-3","title":"Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Merck KGaA; National Heart, Lung, and Blood Institute; Starr Foundation; Memorial Sloan-Kettering Cancer Center; Commonwealth Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; National Center for Research Resources; Weill Cornell Medical College; U.S. Department of Energy","keywords":"Myeloid leukemia; Small hairpin RNA; RNA-binding protein; Leukemia; RNA; Cancer research; Biology; Small molecule; Myeloid; Gene; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003262134,0.00009620097,0.0001371495,0.00008608622,0.00008031917,0.00001485151,0.0008143196,0.0002647479,0.000008980293],"category_scores_gemma":[0.000177451,0.00009670467,0.00007126475,0.000223733,0.00006115982,0.000007001755,0.0005229359,0.0006726275,0.0000107564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005540125,"about_ca_system_score_gemma":0.0001440296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008068669,"about_ca_topic_score_gemma":0.000425817,"domain_scores_codex":[0.9991866,0.0001306263,0.0001611477,0.0001912377,0.0001111538,0.0002192549],"domain_scores_gemma":[0.9985988,0.00006134823,0.00009183899,0.001105951,0.00009142092,0.00005067606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003057971,0.00003739727,0.009391567,0.00001146387,0.00003321262,6.459394e-7,0.00003376033,0.0000181638,0.9891601,0.0002115161,0.0002838282,0.0007878036],"study_design_scores_gemma":[0.0005935029,0.0001021566,0.01500402,0.00004646455,0.00001135957,0.000003210441,0.0001437321,0.001182333,0.9773516,0.00001447544,0.00536164,0.0001855268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993665,0.001516839,0.00005603191,0.0003743677,0.00004324484,0.0002022053,0.0000156761,0.000007861834,0.004118815],"genre_scores_gemma":[0.995865,0.0008032651,0.002282822,0.00007340599,0.00001959164,0.00001641595,0.000144042,0.00001528053,0.0007801409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01180848,"threshold_uncertainty_score":0.3943502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01644004363369907,"score_gpt":0.3016808085426909,"score_spread":0.2852407649089918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}