{"id":"W2952105231","doi":"10.1038/s41467-019-10523-3","title":"Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Merck KGaA; National Heart, Lung, and Blood Institute; Starr Foundation; Memorial Sloan-Kettering Cancer Center; Commonwealth Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; National Center for Research Resources; Weill Cornell Medical College; U.S. Department of Energy","keywords":"Myeloid leukemia; Small hairpin RNA; RNA-binding protein; Leukemia; RNA; Cancer research; Biology; Small molecule; Myeloid; Gene; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780104,0.0002295277,0.0002116834,0.0002135635,0.0001165192,0.0002130301,0.0002311342,0.0001854497,0.0006825943],"category_scores_gemma":[0.00009989306,0.0001043915,0.0001383103,0.0001339914,0.0001908441,0.0001037928,0.0001385822,0.0003194368,0.00023279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000326339,"about_ca_system_score_gemma":0.000183707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003639185,"about_ca_topic_score_gemma":0.001260533,"domain_scores_codex":[0.9999344,0.00001299893,0.000005349004,0.00001109339,0.00002192242,0.00001413658],"domain_scores_gemma":[0.9999547,0.00001103743,0.00001349146,0.000003821008,0.000003520656,0.00001342175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001089936,0.00005212146,0.00007756675,0.00003643394,0.000006347188,0.0000398337,0.000008716628,0.000317896,0.9949926,0.0002968768,0.0000723639,0.003990183],"study_design_scores_gemma":[0.00007755427,0.001020516,0.0011004,0.000004694952,0.00001820278,0.0001597697,0.00000859027,0.001398962,0.9919875,0.00006663343,0.004152395,0.000004836028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869884,0.003022403,0.006807274,0.0001810309,0.00003635157,0.0001022142,0.0002249813,0.0002033013,0.002434015],"genre_scores_gemma":[0.9897848,0.001930771,0.005679306,0.00006478542,0.00001363286,0.0000666745,0.0002618293,0.00001637615,0.002181751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006825943,"threshold_uncertainty_score":0.002367735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01644004363369907,"score_gpt":0.3016808085426909,"score_spread":0.2852407649089918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}