{"id":"W2952137545","doi":"10.1016/j.str.2019.05.003","title":"A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin","year":2019,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Medical Research Council; Merck Sharp and Dohme; Janssen Biotech; Innovative Medicines Initiative; Genome Canada; Francis Crick Institute; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cancer Research UK; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; AbbVie; Merck KGaA; Pfizer","keywords":"Ubiquitin; Ubiquitin ligase; Corepressor; Deubiquitinating enzyme; Cell biology; Chromatin; Chemistry; Ubiquitin-Protein Ligases; NEDD8; Biology; Biochemistry; DNA; Transcription factor; Repressor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007747809,0.0004147524,0.0003211697,0.0002568484,0.0004331869,0.0005068026,0.0002851787,0.0004108352,0.002909917],"category_scores_gemma":[0.00009631884,0.0001720235,0.0002644503,0.0003921462,0.0003321312,0.0003385702,0.0003075474,0.0002824118,0.002182593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004758416,"about_ca_system_score_gemma":0.0002256888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005781907,"about_ca_topic_score_gemma":0.0004168115,"domain_scores_codex":[0.9999515,0.000005983508,0.000002626683,0.00001558402,0.00001440325,0.00000994879],"domain_scores_gemma":[0.9999448,0.000006357935,0.00001783561,0.000009060713,0.000007244293,0.00001457868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002406154,0.00006874026,0.00201238,0.0002778032,0.00004305981,0.0007024952,0.00007675129,0.0009109675,0.9428065,0.007688155,0.001944609,0.04322791],"study_design_scores_gemma":[0.0000387598,0.0003500186,0.02164361,0.00004422365,0.00006039038,0.005383789,0.0001594597,0.003427251,0.8191832,0.003096008,0.1465797,0.00003363806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9028299,0.0212303,0.04735706,0.0008454582,0.0001842849,0.00008460966,0.002217175,0.001337971,0.02391324],"genre_scores_gemma":[0.963096,0.004576575,0.01307592,0.0002137056,0.00004107398,0.00003140533,0.001919238,0.00002878921,0.01701736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002909917,"threshold_uncertainty_score":0.00973469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011123899493337,"score_gpt":0.2334694264918677,"score_spread":0.2223455269985307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}