{"id":"W2952162147","doi":"10.3389/fmicb.2019.01556","title":"Repurposed Antimicrobial Combination Therapy: Tobramycin-Ciprofloxacin Hybrid Augments Activity of the Anticancer Drug Mitomycin C Against Multidrug-Resistant Gram-Negative Bacteria","year":2019,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba","keywords":"Tobramycin; Antimicrobial; Acinetobacter baumannii; Microbiology; Ciprofloxacin; Multiple drug resistance; Pseudomonas aeruginosa; Mitomycin C; Antibiotics; Pharmacology; Medicine; Bacteria; Biology; Gentamicin; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159681,0.0003087452,0.0003027519,0.0002810144,0.0001085552,0.0003887345,0.0002398096,0.0003844313,0.002100704],"category_scores_gemma":[0.00009994185,0.0001114738,0.0003210247,0.0001185817,0.0001743299,0.0002520649,0.0001758648,0.0004079588,0.0004300015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314001,"about_ca_system_score_gemma":0.0001436575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002282515,"about_ca_topic_score_gemma":0.0004394831,"domain_scores_codex":[0.9998606,0.00003319844,0.000006902972,0.00002317041,0.00003755224,0.00003852615],"domain_scores_gemma":[0.9999381,0.00001413563,0.00001605198,0.000006108474,0.00001198834,0.00001349158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001885089,0.0001215724,0.0001538213,0.0001362386,0.000008857977,0.0001008243,0.00001457538,0.0001171125,0.9918457,0.00007630212,0.000162133,0.007074461],"study_design_scores_gemma":[0.00003819793,0.001441265,0.002685856,0.00001463658,0.00003887549,0.0005703474,0.00002820958,0.0009993194,0.9862314,0.00005801128,0.007882705,0.00001115272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732154,0.0147159,0.006015123,0.0005510396,0.0001199306,0.0001299916,0.0003872174,0.0001961095,0.004669188],"genre_scores_gemma":[0.9903476,0.004057338,0.003284101,0.0001124292,0.00003466838,0.00004800942,0.0002064839,0.00001532718,0.001893917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002100704,"threshold_uncertainty_score":0.007027566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004584636422492354,"score_gpt":0.2143785920741909,"score_spread":0.2097939556516985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}